5kq1

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'''Unreleased structure'''
 
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The entry 5kq1 is ON HOLD until Paper Publication
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==Crystal structure of S. pombe Dcp1/Dcp2 in complex with H. sapiens PNRC2==
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<StructureSection load='5kq1' size='340' side='right' caption='[[5kq1]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5kq1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KQ1 FirstGlance]. <br>
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Description:
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kq4|5kq4]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kq1 OCA], [http://pdbe.org/5kq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kq1 RCSB], [http://www.ebi.ac.uk/pdbsum/5kq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kq1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/DCP1_SCHPO DCP1_SCHPO]] Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:15671491</ref> [[http://www.uniprot.org/uniprot/DCP2_SCHPO DCP2_SCHPO]] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:15671491</ref> [[http://www.uniprot.org/uniprot/PNRC2_HUMAN PNRC2_HUMAN]] Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.<ref>PMID:11574675</ref> <ref>PMID:19150429</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gross, J D]]
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[[Category: Jemielity, J]]
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[[Category: Mugridge, J S]]
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[[Category: Ziemniak, M]]
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[[Category: Decapping mrna decay nudix cap analog]]
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[[Category: Hydrolase]]

Revision as of 21:33, 5 October 2016

Crystal structure of S. pombe Dcp1/Dcp2 in complex with H. sapiens PNRC2

5kq1, resolution 3.00Å

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