Zbtb7
From Proteopedia
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==Introduction== | ==Introduction== | ||
| - | Zbtb7 which was originally named as Pokemon (POK erythroid myeloid ontogenic factor) is a gene which plays a critical role in development, cellular differentiation and oncogenesis and has a crucial role in interacting with other POK family proteins.The gene was discovered in 2005 by the team of scientists from Memorial Sloan-Kettering Cancer Center, New York and Institute of Cancer Research, London. Scientists have reported the transcriptional repressor Pokemon as a critical factor in oncogenesis.[1] <Structure load='2NN2' size='350' frame='true' align='right' caption='BTB-zinc finger (BTB-ZF) proteins are transcription regulators with roles in development, differentiation, and oncogenesis. In these proteins, the BTB domain (also known as the POZ domain) is a protein-protein interaction motif that contains a dimerization interface, a possible oligomerization surface' scene=' | + | Zbtb7 which was originally named as Pokemon (POK erythroid myeloid ontogenic factor) is a gene which plays a critical role in development, cellular differentiation and oncogenesis and has a crucial role in interacting with other POK family proteins.The gene was discovered in 2005 by the team of scientists from Memorial Sloan-Kettering Cancer Center, New York and Institute of Cancer Research, London. Scientists have reported the transcriptional repressor Pokemon as a critical factor in oncogenesis.[1] <Structure load='2NN2' size='350' frame='true' align='right' caption='BTB-zinc finger (BTB-ZF) proteins are transcription regulators with roles in development, differentiation, and oncogenesis. In these proteins, the BTB domain (also known as the POZ domain) is a protein-protein interaction motif that contains a dimerization interface, a possible oligomerization surface' scene='<scene name='74/744121/2nn2/1'>TextToBeDisplayed</scene>' /> |
== Function == | == Function == | ||
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Members of the POK family of proteins contain an amino-terminal POZ domain and a carboxy-terminal DNA-binding domain made of Kru¨ppel-type zinc fingers and can act as potent transcriptional repressors through the recruitment of histone deacetylases (HDACs) and subsequent chromatin remodelling.[1] | Members of the POK family of proteins contain an amino-terminal POZ domain and a carboxy-terminal DNA-binding domain made of Kru¨ppel-type zinc fingers and can act as potent transcriptional repressors through the recruitment of histone deacetylases (HDACs) and subsequent chromatin remodelling.[1] | ||
| - | ==References= | + | == References == |
[1] Takahiro Maeda1,2, Robin M. Hobbs1,2, Taha Merghoub1,2, Ilhem Guernah1,2, Arthur Zelent3, Carlos Cordon-Cardo2, Julie Teruya-Feldstein & Pier Paolo Pandolfi1,2. 1Cancer Biology and Genetics Program, 2Department of Pathology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, 1275 York Avenue, New York,New York 10021, USA Leukemia Research Fund Center at the Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK | [1] Takahiro Maeda1,2, Robin M. Hobbs1,2, Taha Merghoub1,2, Ilhem Guernah1,2, Arthur Zelent3, Carlos Cordon-Cardo2, Julie Teruya-Feldstein & Pier Paolo Pandolfi1,2. 1Cancer Biology and Genetics Program, 2Department of Pathology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, 1275 York Avenue, New York,New York 10021, USA Leukemia Research Fund Center at the Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK | ||
Revision as of 19:49, 8 October 2016
Introduction
Zbtb7 which was originally named as Pokemon (POK erythroid myeloid ontogenic factor) is a gene which plays a critical role in development, cellular differentiation and oncogenesis and has a crucial role in interacting with other POK family proteins.The gene was discovered in 2005 by the team of scientists from Memorial Sloan-Kettering Cancer Center, New York and Institute of Cancer Research, London. Scientists have reported the transcriptional repressor Pokemon as a critical factor in oncogenesis.[1]
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