User:Wally Novak/Sandbox Hicks

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Revision as of 08:08, 11 October 2016

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 <StructureSection load='1plq' size='340' side='right' caption='Crystal Structure of Proliferating Cell Nuclear Antigen Found in ''S. cervisiae''' scene=''>
-Proliferating Cell Nuclear Antigen (PCNA) is a cyclic trimer involved with a number of cellular processes. In general, PCNA works as a sliding DNA clamp that anchors proteins, such as DNA polymerase δ (pol δ) to double stranded DNA. Arguably, its most important involvement is in the processive elongation of the leading and lagging strands of DNA in DNA synthesis.
+Proliferating Cell Nuclear Antigen (PCNA) is a cyclic trimer involved with a number of cellular processes. In general, PCNA works as a sliding ring-shaped clamp that anchors replisome proteins to double stranded DNA to prevent dissociation. In processive elongation of the leading and lagging strands of DNA, PCNA assembly is coupled with ATP hydrolysis by Replication Factor C (RFC) onto a primed DNA template. PCNA then associates with DNA polymerase δ (pol δ) creating a holoenzyme such that pol δ synthesizes new DNA strands without dissociating from the DNA template.
 == Interaction with DNA ==