Proliferating Cell Nuclear Antigen (PCNA) is a cyclic trimer involved with a number of cellular processes. In general, PCNA works as a sliding ring-shaped clamp that anchors replisome proteins to double stranded DNA to prevent dissociation. In processive elongation of the leading and lagging strands of DNA, PCNA assembly is coupled with ATP hydrolysis by Replication Factor C (RFC) onto a primed DNA template. PCNA then associates with DNA polymerase δ (pol δ) creating a holoenzyme such that pol δ synthesizes new DNA strands without dissociating from the DNA template.
Structural Highlights
Interaction with DNA
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