2n5y
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n5y OCA], [http://pdbe.org/2n5y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n5y RCSB], [http://www.ebi.ac.uk/pdbsum/2n5y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n5y ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n5y OCA], [http://pdbe.org/2n5y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n5y RCSB], [http://www.ebi.ac.uk/pdbsum/2n5y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n5y ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Tridecaptin A1 (TriA1) is a nonribosomal lipopeptide with selective antimicrobial activity against Gram-negative bacteria. Here we show that TriA1 exerts its bactericidal effect by binding to the bacterial cell-wall precursor lipid II on the inner membrane, disrupting the proton motive force. Biochemical and biophysical assays show that binding to the Gram-negative variant of lipid II is required for membrane disruption and that only the proton gradient is dispersed. The NMR solution structure of TriA1 in dodecylphosphocholine micelles with lipid II has been determined, and molecular modeling was used to provide a structural model of the TriA1-lipid II complex. These results suggest that TriA1 kills Gram-negative bacteria by a mechanism of action using a lipid-II-binding motif. | ||
| + | |||
| + | Antimicrobial lipopeptide tridecaptin A1 selectively binds to Gram-negative lipid II.,Cochrane SA, Findlay B, Bakhtiary A, Acedo JZ, Rodriguez-Lopez EM, Mercier P, Vederas JC Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11561-11566. Epub 2016 Sep 29. PMID:27688760<ref>PMID:27688760</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2n5y" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:19, 19 October 2016
Solution NMR structure of octyl-tridecaptin A1 in DPC micelles containing Gram-negative lipid II
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