1pgr
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pgr OCA], [http://www.ebi.ac.uk/pdbsum/1pgr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pgr RCSB]</span> | ||
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[[Category: signal transduction]] | [[Category: signal transduction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:59:25 2008'' |
Revision as of 19:59, 30 March 2008
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| , resolution 3.5Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR
Overview
Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a non-crystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition.
About this Structure
1PGR is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme., Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K, Nature. 1999 Oct 14;401(6754):713-7. PMID:10537111
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