5l71
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse phospholipid hydroperoxide glutathione peroxidase 4 (GPx4)== | |
| + | <StructureSection load='5l71' size='340' side='right' caption='[[5l71]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5l71]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L71 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipid-hydroperoxide_glutathione_peroxidase Phospholipid-hydroperoxide glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.12 1.11.1.12] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l71 OCA], [http://pdbe.org/5l71 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l71 RCSB], [http://www.ebi.ac.uk/pdbsum/5l71 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l71 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GPX41_MOUSE GPX41_MOUSE]] Protects cells against membrane lipid peroxidation and cell death (PubMed:12566075). Required for normal sperm development and male fertility (PubMed:19417079). Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development (PubMed:12566075). Protects from radiation and oxidative damage (PubMed:12566075). Essential for maturation and survival of photoreceptor cells (PubMed:22207760). Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species, and by supporting T cell expansion (PubMed:25824823).<ref>PMID:12566075</ref> <ref>PMID:18762024</ref> <ref>PMID:19417079</ref> <ref>PMID:22207760</ref> <ref>PMID:25824823</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The mammalian glutathione peroxidase (GPx) family is a key component of the cellular antioxidative defence system. Within this family, GPx4 has unique features as it accepts a large class of hydroperoxy lipid substrates and has a plethora of biological functions, including sperm maturation, regulation of apoptosis and cerebral embryogenesis. In this paper, the structure of the cytoplasmic isoform of mouse phospholipid hydroperoxide glutathione peroxidase (O70325-2 GPx4) with selenocysteine 46 mutated to cysteine is reported solved at 1.8 A resolution using X-ray crystallography. Furthermore, solution data of an isotope-labelled GPx protein are presented. | ||
| - | + | Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.,Janowski R, Scanu S, Niessing D, Madl T Acta Crystallogr F Struct Biol Commun. 2016 Oct 1;72(Pt 10):743-749. Epub 2016, Sep 22. PMID:27710939<ref>PMID:27710939</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5l71" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Phospholipid-hydroperoxide glutathione peroxidase]] | ||
| + | [[Category: Janowski, R]] | ||
| + | [[Category: Madl, T]] | ||
[[Category: Niessing, D]] | [[Category: Niessing, D]] | ||
[[Category: Scanu, S]] | [[Category: Scanu, S]] | ||
| - | [[Category: | + | [[Category: Oxidoreductase]] |
| - | [[Category: | + | [[Category: Selenocysteine]] |
Revision as of 17:22, 19 October 2016
Crystal structure of mouse phospholipid hydroperoxide glutathione peroxidase 4 (GPx4)
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