5j3r

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'''Unreleased structure'''
 
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The entry 5j3r is ON HOLD until Paper Publication
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==Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster==
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<StructureSection load='5j3r' size='340' side='right' caption='[[5j3r]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5j3r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J3R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J3R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j3r OCA], [http://pdbe.org/5j3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j3r RCSB], [http://www.ebi.ac.uk/pdbsum/5j3r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j3r ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glutaredoxins (Grxs) constitute a superfamily of proteins that perform diverse biological functions. The Saccharomyces cerevisiae glutaredoxin Grx6 not only serves as a glutathione (GSH)-dependent oxidoreductase and as a GSH transferase, but also as an essential [2Fe-2S]-binding protein. Here, the dimeric structure of the C-terminal domain of Grx6 (holo Grx6C), bridged by one [2Fe-2S] cluster coordinated by the active-site Cys136 and two external GSH molecules, is reported. Structural comparison combined with multiple-sequence alignment demonstrated that holo Grx6C is similar to the [2Fe-2S] cluster-incorporated dithiol Grxs, which share a highly conserved [2Fe-2S] cluster-binding pattern and dimeric conformation that is distinct from the previously identified [2Fe-2S] cluster-ligated monothiol Grxs.
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Authors:
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Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster.,Abdalla M, Dai YN, Chi CB, Cheng W, Cao DD, Zhou K, Ali W, Chen Y, Zhou CZ Acta Crystallogr F Struct Biol Commun. 2016 Oct 1;72(Pt 10):732-737. Epub 2016, Sep 22. PMID:27710937<ref>PMID:27710937</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 5j3r" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Abdalla, M]]
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[[Category: Ali, W]]
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[[Category: Cao, D D]]
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[[Category: Chen, Y]]
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[[Category: Cheng, W]]
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[[Category: Chi, C B]]
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[[Category: Dai, Y N]]
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[[Category: Zhou, C Z]]
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[[Category: Zhou, K]]
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[[Category: Glutaredoxin]]
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[[Category: Iron-sulfur cluster]]
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[[Category: Oxidoreductase]]
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[[Category: Saccharomyces cerevisiae]]

Revision as of 17:32, 19 October 2016

Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster

5j3r, resolution 2.46Å

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