2n8j
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure and 15N relaxation data of Calmodulin bound to the endothelial Nitric Oxide Synthase Calmodulin Binding Domain Peptide at Physiological Calcium Concentration== | |
| - | + | <StructureSection load='2n8j' size='340' side='right' caption='[[2n8j]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2n8j]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N8J FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n8j OCA], [http://pdbe.org/2n8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n8j RCSB], [http://www.ebi.ac.uk/pdbsum/2n8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n8j ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref> Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Dieckmann, T]] | [[Category: Dieckmann, T]] | ||
[[Category: Guillemette, G]] | [[Category: Guillemette, G]] | ||
| + | [[Category: Piazza, M]] | ||
| + | [[Category: Calmodulin]] | ||
| + | [[Category: Dynamic]] | ||
| + | [[Category: Eno]] | ||
| + | [[Category: Nitric oxide synthase]] | ||
| + | [[Category: Order parameter]] | ||
| + | [[Category: Protein binding]] | ||
Revision as of 17:35, 19 October 2016
Structure and 15N relaxation data of Calmodulin bound to the endothelial Nitric Oxide Synthase Calmodulin Binding Domain Peptide at Physiological Calcium Concentration
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