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5e7d
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand== | |
| - | + | <StructureSection load='5e7d' size='340' side='right' caption='[[5e7d]], [[Resolution|resolution]] 1.87Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5e7d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E7D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5KL:(2E)-3-(DIMETHYLAMINO)-1-(2-HYDROXYPHENYL)PROP-2-EN-1-ONE'>5KL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e7d OCA], [http://pdbe.org/5e7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e7d RCSB], [http://www.ebi.ac.uk/pdbsum/5e7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e7d ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
| - | [[Category: | + | [[Category: Delft, F von]] |
| - | [[Category: | + | [[Category: Edwards, A]] |
[[Category: Filippakopoulos, P]] | [[Category: Filippakopoulos, P]] | ||
| - | [[Category: | + | [[Category: Knapp, S]] |
| - | + | ||
[[Category: Owen, D]] | [[Category: Owen, D]] | ||
| + | [[Category: Picaud, S]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Bromodomain]] | ||
| + | [[Category: Chemical probe]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Ligand]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 17:37, 19 October 2016
Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand
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Categories: Arrowsmith, C H | Bountra, C | Delft, F von | Edwards, A | Filippakopoulos, P | Knapp, S | Owen, D | Picaud, S | Structural genomic | Bromodomain | Chemical probe | Inhibitor | Ligand | Sgc | Transcription
