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5luu

From Proteopedia

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m (Protected "5luu" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5luu is ON HOLD
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==Structure of the first bromodomain of BRD4 with a pyrazolo[4,3-c]pyridin fragment==
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<StructureSection load='5luu' size='340' side='right' caption='[[5luu]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
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Authors: Filippakopoulos, P., Picaud, S., Knapp, S., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5luu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LUU FirstGlance]. <br>
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Description: Structure of the first bromodomain of BRD4 with a pyrazolo[4,3-c]pyridin fragment
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=77X:1-(3-PHENYL-1,4,6,7-TETRAHYDROPYRAZOLO[4,3-C]PYRIDIN-5-YL)PROPAN-1-ONE'>77X</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5luu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5luu OCA], [http://pdbe.org/5luu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5luu RCSB], [http://www.ebi.ac.uk/pdbsum/5luu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5luu ProSAT]</span></td></tr>
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[[Category: Picaud, S]]
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</table>
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[[Category: Knapp, S]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Delft, F von]]
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[[Category: Von Delft, F]]
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[[Category: Edwards, A]]
[[Category: Filippakopoulos, P]]
[[Category: Filippakopoulos, P]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Knapp, S]]
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[[Category: Edwards, A]]
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[[Category: Picaud, S]]
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[[Category: Structural genomic]]
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[[Category: Bromodomain]]
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[[Category: Complex]]
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[[Category: Fragment]]
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[[Category: Sgc]]
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[[Category: Transcription]]

Revision as of 17:45, 19 October 2016

Structure of the first bromodomain of BRD4 with a pyrazolo[4,3-c]pyridin fragment

5luu, resolution 1.61Å

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