5lru

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m (Protected "5lru" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5lru is ON HOLD
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==Structure of Cezanne/OTUD7B OTU domain==
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<StructureSection load='5lru' size='340' side='right' caption='[[5lru]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5lru]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LRU FirstGlance]. <br>
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Description:
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lru OCA], [http://pdbe.org/5lru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lru RCSB], [http://www.ebi.ac.uk/pdbsum/5lru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lru ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/OTU7B_HUMAN OTU7B_HUMAN]] Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.<ref>PMID:11463333</ref> <ref>PMID:12682062</ref> <ref>PMID:18178551</ref> <ref>PMID:20622874</ref> <ref>PMID:22179831</ref> <ref>PMID:23827681</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Ubiquitinyl hydrolase 1]]
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[[Category: Akutsu, M]]
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[[Category: Burke, J E]]
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[[Category: Elliott, P R]]
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[[Category: Freund, S M.V]]
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[[Category: Gersch, M]]
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[[Category: Geurink, P P]]
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[[Category: Kawasaki, M]]
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[[Category: Komander, D]]
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[[Category: Kulathu, Y]]
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[[Category: Maslen, S L]]
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[[Category: Mevissen, T E.T]]
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[[Category: Mulder, M P.C]]
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[[Category: Oualid, F El]]
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[[Category: Ovaa, H]]
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[[Category: Tol, B D.M van]]
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[[Category: Deubiquitinase]]
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[[Category: Hydrolase]]
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[[Category: Otu domain]]
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[[Category: Protease]]

Revision as of 01:01, 20 October 2016

Structure of Cezanne/OTUD7B OTU domain

5lru, resolution 2.20Å

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