1pmi
From Proteopedia
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|PDB= 1pmi |SIZE=350|CAPTION= <scene name='initialview01'>1pmi</scene>, resolution 1.7Å | |PDB= 1pmi |SIZE=350|CAPTION= <scene name='initialview01'>1pmi</scene>, resolution 1.7Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Mannose-6-phosphate_isomerase Mannose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.8 5.3.1.8] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannose-6-phosphate_isomerase Mannose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.8 5.3.1.8] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pmi OCA], [http://www.ebi.ac.uk/pdbsum/1pmi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pmi RCSB]</span> | ||
}} | }} | ||
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[[Category: Wells, T N.C.]] | [[Category: Wells, T N.C.]] | ||
[[Category: Wonacott, A.]] | [[Category: Wonacott, A.]] | ||
| - | [[Category: ZN]] | ||
[[Category: aldose-ketose isomerase]] | [[Category: aldose-ketose isomerase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:01:39 2008'' |
Revision as of 20:01, 30 March 2008
| |||||||
| , resolution 1.7Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Mannose-6-phosphate isomerase, with EC number 5.3.1.8 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN RANTES
Overview
Phosphomannose isomerase (PMI) catalyses the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P). Absence of PMI activity in yeasts causes cell lysis and thus the enzyme is a potential target for inhibition and may be a route to antifungal drugs. The 1.7 A crystal structure of PMI from Candida albicans shows that the enzyme has three distinct domains. The active site lies in the central domain, contains a single essential zinc atom, and forms a deep, open cavity of suitable dimensions to contain M6P or F6P The central domain is flanked by a helical domain on one side and a jelly-roll like domain on the other.
About this Structure
1PMI is a Single protein structure of sequence from Candida albicans. Full crystallographic information is available from OCA.
Reference
The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution., Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ, Proudfoot AE, Bernard AR, Payton MA, Wells TN, Nat Struct Biol. 1996 May;3(5):470-9. PMID:8612079
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