5fah
From Proteopedia
(Difference between revisions)
m (Protected "5fah" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==KALLIKREIN-7 IN COMPLEX WITH COMPOUND1== | |
| - | + | <StructureSection load='5fah' size='340' side='right' caption='[[5fah]], [[Resolution|resolution]] 1.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FAH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5VT:(2~{S})-~{N}2-[2-(4-METHOXYPHENYL)ETHYL]-~{N}1-(NAPHTHALEN-1-YLMETHYL)PYRROLIDINE-1,2-DICARBOXAMIDE'>5VT</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stratum_corneum_chymotryptic_enzyme Stratum corneum chymotryptic enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.117 3.4.21.117] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fah OCA], [http://pdbe.org/5fah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fah RCSB], [http://www.ebi.ac.uk/pdbsum/5fah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fah ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KLK7_HUMAN KLK7_HUMAN]] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Stratum corneum chymotryptic enzyme]] | ||
[[Category: Ostermann, N]] | [[Category: Ostermann, N]] | ||
[[Category: Zink, F]] | [[Category: Zink, F]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 18:40, 26 October 2016
KALLIKREIN-7 IN COMPLEX WITH COMPOUND1
| |||||||||||
