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5gxi

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'''Unreleased structure'''
 
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The entry 5gxi is ON HOLD until Paper Publication
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==Strucutre of the Gemin5 WD40 domain in complex with AAUUUUUGAG==
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<StructureSection load='5gxi' size='340' side='right' caption='[[5gxi]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5gxi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GXI FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gxh|5gxh]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gxi OCA], [http://pdbe.org/5gxi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gxi RCSB], [http://www.ebi.ac.uk/pdbsum/5gxi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gxi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GEMI5_HUMAN GEMI5_HUMAN]] The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex.<ref>PMID:11714716</ref> <ref>PMID:16857593</ref> <ref>PMID:18984161</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Dong, A]]
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[[Category: Edwards, A M]]
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[[Category: He, H]]
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[[Category: Li, Y]]
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[[Category: Min, J]]
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[[Category: Structural genomic]]
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[[Category: Xu, C]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Sgc]]
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[[Category: Snrna]]
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[[Category: Snrnp assembly]]

Revision as of 18:43, 26 October 2016

Strucutre of the Gemin5 WD40 domain in complex with AAUUUUUGAG

5gxi, resolution 1.85Å

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