5ldz
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Quadruple space group ambiguity due to rotational and translational non-crystallographic symmetry in human liver fructose-1,6-bisphosphatase== | |
| - | + | <StructureSection load='5ldz' size='340' side='right' caption='[[5ldz]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ldz]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LDZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LDZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ldz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ldz OCA], [http://pdbe.org/5ldz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ldz RCSB], [http://www.ebi.ac.uk/pdbsum/5ldz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ldz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[http://omim.org/entry/229700 229700]]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fructose-bisphosphatase]] | ||
| + | [[Category: Joseph, C]] | ||
| + | [[Category: Rudolph, M G]] | ||
[[Category: Ruf, A]] | [[Category: Ruf, A]] | ||
| + | [[Category: Schott, B]] | ||
[[Category: Tetaz, T]] | [[Category: Tetaz, T]] | ||
| - | [[Category: | + | [[Category: Allosteric enzyme]] |
| - | [[Category: | + | [[Category: Carbohydrate]] |
| - | [[Category: | + | [[Category: Gluconeogenesis]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Metabolism]] | ||
| + | [[Category: Phosphoric monoester]] | ||
Revision as of 18:48, 26 October 2016
Quadruple space group ambiguity due to rotational and translational non-crystallographic symmetry in human liver fructose-1,6-bisphosphatase
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