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5lof
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1== | |
| - | + | <StructureSection load='5lof' size='340' side='right' caption='[[5lof]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lof]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=70R:(2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic+acid'>70R</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lof OCA], [http://pdbe.org/5lof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lof RCSB], [http://www.ebi.ac.uk/pdbsum/5lof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lof ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Balint, B]] | [[Category: Balint, B]] | ||
| - | [[Category: | + | [[Category: Blasko, G]] |
| + | [[Category: Chen, I]] | ||
| + | [[Category: Csekei, M]] | ||
[[Category: Davidson, J]] | [[Category: Davidson, J]] | ||
| - | [[Category: Szabo, Z]] | ||
| - | [[Category: Blasko, G]] | ||
| - | [[Category: Szlavik, Z]] | ||
| - | [[Category: Proszenyak, A]] | ||
| - | [[Category: Murray, J]] | ||
[[Category: Dokurno, P]] | [[Category: Dokurno, P]] | ||
[[Category: Geneste, O]] | [[Category: Geneste, O]] | ||
| - | [[Category: | + | [[Category: Graham, C]] |
| - | [[Category: | + | [[Category: Kotschy, A]] |
| - | [[Category: | + | [[Category: Matassova, N]] |
| + | [[Category: Murray, J]] | ||
| + | [[Category: Ondi, L]] | ||
| + | [[Category: Paczal, A]] | ||
| + | [[Category: Pedder, C]] | ||
| + | [[Category: Proszenyak, A]] | ||
| + | [[Category: Radics, G]] | ||
[[Category: Robertson, A]] | [[Category: Robertson, A]] | ||
| + | [[Category: Sipos, S]] | ||
[[Category: Smith, J]] | [[Category: Smith, J]] | ||
| - | [[Category: | + | [[Category: Surgenor, A]] |
| - | [[Category: | + | [[Category: Szabo, Z]] |
| - | [[Category: | + | [[Category: Szlavik, Z]] |
| - | [[Category: | + | [[Category: Apoptosis-inhibitor complex]] |
| - | [[Category: | + | [[Category: Mbp]] |
| + | [[Category: Mcl-1]] | ||
| + | [[Category: S s63845]] | ||
Revision as of 18:48, 26 October 2016
Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1
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Categories: Balint, B | Blasko, G | Chen, I | Csekei, M | Davidson, J | Dokurno, P | Geneste, O | Graham, C | Kotschy, A | Matassova, N | Murray, J | Ondi, L | Paczal, A | Pedder, C | Proszenyak, A | Radics, G | Robertson, A | Sipos, S | Smith, J | Surgenor, A | Szabo, Z | Szlavik, Z | Apoptosis-inhibitor complex | Mbp | Mcl-1 | S s63845
