5lwb

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'''Unreleased structure'''
 
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The entry 5lwb is ON HOLD
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==Crystal structure of human JARID1B in complex with S40650a==
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<StructureSection load='5lwb' size='340' side='right' caption='[[5lwb]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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Authors: Srikannathasan, V., Le Bihan, Y.V., Szykowska, A., Johansson, C., Gileadi, C., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Oppermann, U., Huber, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5lwb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LWB FirstGlance]. <br>
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Description: Crystal structure of human JARID1B in complex with S40650a
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=79H:5-[1-[2-(DIMETHYLAMINO)ETHYL]PYRAZOL-4-YL]-7-OXIDANYLIDENE-6-PROPAN-2-YL-6~{H}-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE'>79H</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lwb OCA], [http://pdbe.org/5lwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lwb RCSB], [http://www.ebi.ac.uk/pdbsum/5lwb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lwb ProSAT]</span></td></tr>
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[[Category: Le Bihan, Y.V]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bihan, Y V.Le]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M]]
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[[Category: Gileadi, C]]
[[Category: Huber, K]]
[[Category: Huber, K]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Johansson, C]]
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[[Category: Gileadi, C]]
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[[Category: Oppermann, U]]
[[Category: Oppermann, U]]
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[[Category: Srikannathasan, V]]
[[Category: Szykowska, A]]
[[Category: Szykowska, A]]
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[[Category: Von Delft, F]]
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[[Category: Lysine-specific demethylase 5b]]
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[[Category: Edwards, A.M]]
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[[Category: Oxidoreductase]]
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[[Category: Johansson, C]]
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[[Category: Srikannathasan, V]]
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Revision as of 18:48, 26 October 2016

Crystal structure of human JARID1B in complex with S40650a

5lwb, resolution 2.39Å

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