5sym
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cocrystal structure of the human acyl protein thioesterase 1 with an isoform-selective inhibitor, ML348== | |
| - | + | <StructureSection load='5sym' size='340' side='right' caption='[[5sym]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5sym]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SYM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=71Q:N-[2-CHLORO-5-(TRIFLUOROMETHYL)PHENYL]-2-[4-(FURAN-2-CARBONYL)PIPERAZIN-1-YL]ACETAMIDE'>71Q</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5syn|5syn]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5sym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sym OCA], [http://pdbe.org/5sym PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5sym RCSB], [http://www.ebi.ac.uk/pdbsum/5sym PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5sym ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LYPA1_HUMAN LYPA1_HUMAN]] Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity.<ref>PMID:20418879</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Labby, K J]] | ||
| + | [[Category: Martin, B R]] | ||
| + | [[Category: Meagher, J L]] | ||
| + | [[Category: Stuckey, J A]] | ||
| + | [[Category: Won, S J]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Thioesterase]] | ||
Revision as of 18:49, 26 October 2016
Cocrystal structure of the human acyl protein thioesterase 1 with an isoform-selective inhibitor, ML348
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