5tia
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target HR6161== | |
| - | + | <StructureSection load='5tia' size='340' side='right' caption='[[5tia]], [[Resolution|resolution]] 2.44Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tia]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TIA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ti9|5ti9]]</td></tr> |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tia OCA], [http://pdbe.org/5tia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tia RCSB], [http://www.ebi.ac.uk/pdbsum/5tia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tia ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN]] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Tryptophan 2,3-dioxygenase]] | ||
[[Category: Forouhar, F]] | [[Category: Forouhar, F]] | ||
| + | [[Category: Structural genomic]] | ||
[[Category: Tong, L]] | [[Category: Tong, L]] | ||
| + | [[Category: 3-dioxygenase]] | ||
| + | [[Category: Human tryptophan 2]] | ||
| + | [[Category: Nesg]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Psi-biology]] | ||
Revision as of 18:51, 26 October 2016
Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target HR6161
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