3-phosphoinositide-dependent protein kinase 1

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*Pdk1 kinase domain
*Pdk1 kinase domain
-
**[[1h1w]] – hPdk1 kd + PSer – human <br />
+
**[[1h1w]] – hPdk1 + PSer – human <br />
-
**[[1uu3]], [[1uu7]], [[1uu8]], [[1uu9]], [[1uvr]], [[1z5m]], [[2pe0]], [[2pe1]], [[2pe2]], [[3h9o]], [[2xch]], [[2xck]], [[3qcq]], [[3qcs]], [[3qcx]], [[3qcy]], [[3qd0]], [[3qd3]], [[3qd4]], [[3nus]], [[3nuu]], [[3nuy]], [[3nun]], [[3sc1]], [[3rwp]], [[3rwq]] – hPdk1 kd + PSer + inhibitor <br />
+
**[[1uu3]], [[1uu7]], [[1uu8]], [[1uu9]], [[1uvr]], [[1z5m]], [[2pe0]], [[2pe1]], [[2pe2]], [[3h9o]], [[2xch]], [[2xck]], [[3qcq]], [[3qcs]], [[3qcx]], [[3qcy]], [[3qd0]], [[3qd3]], [[3qd4]], [[3nus]], [[3nuu]], [[3nuy]], [[3nun]], [[3sc1]], [[3rwp]], [[3rwq]], [[5hkm]], [[5hng]], [[5ho7]], [[5ho8]] – hPdk1 + PSer + inhibitor <br />
-
**[[3orx]], [[3orz]], [[3otu]], [[3qc4]], [[3rcj]] – hPdk1 kd (mutant) + PSer + inhibitor <br />
+
**[[3orx]], [[3orz]], [[3otu]], [[3qc4]], [[3rcj]], [[5lvl]], [[4xx9]], [[5ack]] – hPdk1 (mutant) + PSer + inhibitor <br />
-
**[[2r7b]], [[3ion]], [[3iop]], [[3nax]], [[3nay]] – hPdk1 kd + inhibitor <br />
+
**[[2r7b]], [[3ion]], [[3iop]], [[3nax]], [[3nay]] – hPdk1 + inhibitor <br />
-
**[[3pwy]] – hPdk1 kd (mutant) + inhibitor <br />
+
**[[3pwy]] – hPdk1 (mutant) + inhibitor <br />
-
**[[1oky]], [[1okz]] – hPdk1 kd + PSer + staurosporine <br />
+
**[[1oky]], [[1okz]] – hPdk1 + PSer + staurosporine <br />
-
**[[2biy]], [[3hrc]] – hPdk1 kd (mutant) + ATP <br />
+
**[[2biy]], [[3hrc]] – hPdk1 (mutant) + ATP <br />
-
**[[4ct1]] – hPdk1 kd (mutant) + ATP + PSer + PS315<br />
+
**[[4ct1]] – hPdk1 (mutant) + ATP + PSer + PS315<br />
-
**[[4ct2]] – hPdk1 kd (mutant) + ATP + PSer <br />
+
**[[5lvo]] – hPdk1 (mutant) + ATP + PSer + PSE10<br />
-
**[[4rqk]], [[4rqv]] – hPdk1 kd (mutant) + ATP + PSer + inhibitor<br />
+
**[[5lvp]] – hPdk1 (mutant) + ATP + PSer + peptide<br />
-
**[[4rrv]] – hPdk1 kd (mutant) + ATP + PSer + serine/threonine protein kinase N2<br />
+
**[[4ct2]] – hPdk1 (mutant) + ATP + PSer <br />
-
 
+
**[[5lvm]] – hPdk1 (mutant) + adenine + PSer <br />
-
**[[3hrf]], [[4a06]], [[4a07]], [[4aw0]], [[4aw1]] – hPdk1 kd (mutant) + PSer + ATP + activator<br />
+
**[[5lvn]] – hPdk1 (mutant) + adenosine + PSer <br />
 +
**[[4rqk]], [[4rqv]] – hPdk1 (mutant) + ATP + PSer + inhibitor<br />
 +
**[[4rrv]] – hPdk1 (mutant) + ATP + PSer + serine/threonine protein kinase N2<br />
 +
**[[3hrf]], [[4a06]], [[4a07]], [[4aw0]], [[4aw1]] – hPdk1 (mutant) + PSer + ATP + activator<br />
*Pdk1 PH domain
*Pdk1 PH domain
-
**[[1w1h]] – hPdk1 PH domain <br />
+
**[[1w1h]] – hPdkl <br />
-
**[[2vki]] – hPdk1 PH domain (mutant)<br />
+
**[[2vki]] – hPdk1 (mutant)<br />
-
**[[1w1d]], [[1w1g]] – hPdk1 PH domain + inositol phosphate <br />
+
**[[1w1d]], [[1w1g]] – hPdk1 + inositol phosphate <br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 15:06, 31 October 2016

Human Pdk1 kinase domain containing phosphorylated serine 241 complex with pyrazoloquinazoline inhibitor, sulfate and glycerol (PDB entry 2xch)

Drag the structure with the mouse to rotate

3D Structures of Pdk1

Updated on 31-October-2016

References

  1. ↑ Mora A, Komander D, van Aalten DM, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol. 2004 Apr;15(2):161-70. PMID:15209375

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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