5l44
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l44 OCA], [http://pdbe.org/5l44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l44 RCSB], [http://www.ebi.ac.uk/pdbsum/5l44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l44 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l44 OCA], [http://pdbe.org/5l44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l44 RCSB], [http://www.ebi.ac.uk/pdbsum/5l44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l44 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Several soil-derived actinobacteria produce secondary metabolites that are proven specific and potent inhibitors of the human angiotensin-I converting enzyme (ACE), a key target for the modulation of hypertension through its role in the renin-angiotensin-aldosterone system. K-26-DCP is a zinc dipeptidyl carboxypeptidase produced by Astrosporangium hypotensionis, and an ancestral homologue of ACE. Here we report the high resolution crystal structures of K-26-DCP and of its complex with the natural microbial tripeptide product K-26. The experimental results provide the structural basis for better understanding the specificity of K-26 for human ACE over bacterial DCPs. This article is protected by copyright. All rights reserved. | ||
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| + | Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor.,Masuyer G, Cozier GE, Kramer GJ, Bachmann BO, Acharya KR FEBS J. 2016 Oct 18. doi: 10.1111/febs.13928. PMID:27754586<ref>PMID:27754586</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5l44" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:03, 2 November 2016
Structure of K-26-DCP in complex with the K-26 tripeptide
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