1ps1
From Proteopedia
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|PDB= 1ps1 |SIZE=350|CAPTION= <scene name='initialview01'>1ps1</scene>, resolution 2.60Å | |PDB= 1ps1 |SIZE=350|CAPTION= <scene name='initialview01'>1ps1</scene>, resolution 2.60Å | ||
|SITE= <scene name='pdbsite=AR1:Aspartate-Rich+Region,+Monomer+A'>AR1</scene> and <scene name='pdbsite=AR2:Aspartate-Rich+Region,+Monomer+B'>AR2</scene> | |SITE= <scene name='pdbsite=AR1:Aspartate-Rich+Region,+Monomer+A'>AR1</scene> and <scene name='pdbsite=AR2:Aspartate-Rich+Region,+Monomer+B'>AR2</scene> | ||
| - | |LIGAND= <scene name='pdbligand=PBM:TRIMETHYL LEAD ION'>PBM</scene> | + | |LIGAND= <scene name='pdbligand=PBM:TRIMETHYL+LEAD+ION'>PBM</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/ | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pentalenene_synthase Pentalenene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.7 4.2.3.7] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ps1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ps1 OCA], [http://www.ebi.ac.uk/pdbsum/1ps1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ps1 RCSB]</span> | ||
}} | }} | ||
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==Reference== | ==Reference== | ||
Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology., Lesburg CA, Zhai G, Cane DE, Christianson DW, Science. 1997 Sep 19;277(5333):1820-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9295272 9295272] | Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology., Lesburg CA, Zhai G, Cane DE, Christianson DW, Science. 1997 Sep 19;277(5333):1820-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9295272 9295272] | ||
| + | [[Category: Pentalenene synthase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptomyces sp.]] | [[Category: Streptomyces sp.]] | ||
| - | [[Category: Transferred entry: 4 2.3 7]] | ||
[[Category: Christianson, D W.]] | [[Category: Christianson, D W.]] | ||
[[Category: Lesburg, C A.]] | [[Category: Lesburg, C A.]] | ||
| - | [[Category: PBM]] | ||
[[Category: antibiotic biosynthesis]] | [[Category: antibiotic biosynthesis]] | ||
[[Category: lyase]] | [[Category: lyase]] | ||
[[Category: sesquiterpene cyclase]] | [[Category: sesquiterpene cyclase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:03:46 2008'' |
Revision as of 20:03, 30 March 2008
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| , resolution 2.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | and | ||||||
| Ligands: | |||||||
| Activity: | Pentalenene synthase, with EC number 4.2.3.7 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PENTALENENE SYNTHASE
Overview
The crystal structure of pentalenene synthase at 2.6 angstrom resolution reveals critical active site features responsible for the cyclization of farnesyl diphosphate into the tricyclic hydrocarbon pentalenene. Metal-triggered substrate ionization initiates catalysis, and the alpha-barrel active site serves as a template to channel and stabilize the conformations of reactive carbocation intermediates through a complex cyclization cascade. The core active site structure of the enzyme may be preserved among the greater family of terpenoid synthases, possibly implying divergence from a common ancestral synthase to satisfy biological requirements for increasingly diverse natural products.
About this Structure
1PS1 is a Single protein structure of sequence from Streptomyces sp.. Full crystallographic information is available from OCA.
Reference
Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology., Lesburg CA, Zhai G, Cane DE, Christianson DW, Science. 1997 Sep 19;277(5333):1820-4. PMID:9295272
Page seeded by OCA on Sun Mar 30 23:03:46 2008
