1psj
From Proteopedia
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|PDB= 1psj |SIZE=350|CAPTION= <scene name='initialview01'>1psj</scene>, resolution 2.0Å | |PDB= 1psj |SIZE=350|CAPTION= <scene name='initialview01'>1psj</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [http://www.ebi.ac.uk/pdbsum/1psj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB]</span> | ||
}} | }} | ||
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[[Category: Lin, Z J.]] | [[Category: Lin, Z J.]] | ||
[[Category: Wang, X Q.]] | [[Category: Wang, X Q.]] | ||
| - | [[Category: CA]] | ||
[[Category: calcium]] | [[Category: calcium]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
[[Category: lipid degradation]] | [[Category: lipid degradation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:04:02 2008'' |
Revision as of 20:04, 30 March 2008
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| , resolution 2.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Phospholipase A(2), with EC number 3.1.1.4 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS
Overview
The crystal structure of acidic phospholipase A2 from the venom of Agkistrodon halys pallas has been determined by molecular replacement at 2.0 A resolution to a crystallographic R-factor of 0.157. The overall structure of the molecule is very similar to those of other phospholipase A2 species of known structure. The catalytic site, the hydrophobic channel and the N-terminal region show greatest structural conservation. The Ca(2+)-binding region has a conformation that resembles closely that of bovine PLA2 rather than Crotalus atrox PLA2. Compared with other PLA2 species, the conformation of the C-terminal ridge shows significant difference due to the insertion of two residues. A unique aromatic patch appears on one face of the molecules, surrounded by two acidic residues, the relevant features of this structure and their possible biological implications are discussed.
About this Structure
1PSJ is a Single protein structure of sequence from Gloydius halys. Full crystallographic information is available from OCA.
Reference
Crystal structure of an acidic phospholipase A2 from the venom of Agkistrodon halys pallas at 2.0 A resolution., Wang XQ, Yang J, Gui LL, Lin ZJ, Chen YC, Zhou YC, J Mol Biol. 1996 Feb 9;255(5):669-76. PMID:8636969
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