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5grj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human PD-L1 with monoclonal antibody avelumab== | |
| - | + | <StructureSection load='5grj' size='340' side='right' caption='[[5grj]], [[Resolution|resolution]] 3.21Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5grj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GRJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5grj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5grj OCA], [http://pdbe.org/5grj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5grj RCSB], [http://www.ebi.ac.uk/pdbsum/5grj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5grj ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chai, Y]] | ||
| + | [[Category: Chen, D]] | ||
| + | [[Category: Gao, G F]] | ||
| + | [[Category: Gao, S]] | ||
| + | [[Category: Liu, J]] | ||
| + | [[Category: Liu, K]] | ||
| + | [[Category: Lyu, J]] | ||
| + | [[Category: Qi, J]] | ||
| + | [[Category: Shi, Y]] | ||
| + | [[Category: Song, H]] | ||
[[Category: Tan, S]] | [[Category: Tan, S]] | ||
| - | [[Category: Gao, G.F]] | ||
[[Category: Tan, W]] | [[Category: Tan, W]] | ||
| - | [[Category: Liu, J]] | ||
| - | [[Category: Song, H]] | ||
| - | [[Category: Shi, Y]] | ||
| - | [[Category: Gao, S]] | ||
| - | [[Category: Lyu, J]] | ||
| - | [[Category: Chai, Y]] | ||
| - | [[Category: Liu, K]] | ||
| - | [[Category: Chen, D]] | ||
[[Category: Yan, J]] | [[Category: Yan, J]] | ||
| - | [[Category: Zhang, C | + | [[Category: Zhang, C W.H]] |
| - | [[Category: | + | [[Category: Avelumab]] |
| + | [[Category: Immune system]] | ||
| + | [[Category: Monoclonal antibody]] | ||
| + | [[Category: Pd-l1]] | ||
| + | [[Category: Tumor immunothepapy]] | ||
Revision as of 18:18, 2 November 2016
Crystal structure of human PD-L1 with monoclonal antibody avelumab
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Categories: Chai, Y | Chen, D | Gao, G F | Gao, S | Liu, J | Liu, K | Lyu, J | Qi, J | Shi, Y | Song, H | Tan, S | Tan, W | Yan, J | Zhang, C W.H | Avelumab | Immune system | Monoclonal antibody | Pd-l1 | Tumor immunothepapy
