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5gqq

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'''Unreleased structure'''
 
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The entry 5gqq is ON HOLD until Paper Publication
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==Structure of ALG-2/HEBP2 Complex==
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<StructureSection load='5gqq' size='340' side='right' caption='[[5gqq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5gqq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GQQ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gqq OCA], [http://pdbe.org/5gqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gqq RCSB], [http://www.ebi.ac.uk/pdbsum/5gqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gqq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HEBP2_HUMAN HEBP2_HUMAN]] Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.<ref>PMID:17098234</ref> [[http://www.uniprot.org/uniprot/PDCD6_HUMAN PDCD6_HUMAN]] Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.<ref>PMID:16132846</ref> <ref>PMID:19520058</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Feng, Y]]
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[[Category: Liu, X]]
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[[Category: Ma, J]]
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[[Category: Zhang, H]]
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[[Category: Apoptosis]]
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[[Category: Calcium ion]]
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[[Category: Complex]]
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[[Category: Ef hand]]

Revision as of 18:28, 2 November 2016

Structure of ALG-2/HEBP2 Complex

5gqq, resolution 2.20Å

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