User:Bailey Dove/Sandbox1
From Proteopedia
(Difference between revisions)
(New page: ==Hepatitis C== The Hepatitis C virus (HCV) is a blood-borne, single stranded RNA virus. <ref>Centers for Disease Control and Prevention. (2015). Viral hepatitis - hepatitis C information....) |
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==Victrelis== | ==Victrelis== | ||
| - | Victrelis (boceprevir) is an antiviral Hepatitis C medication approved by the United States Food and Drug Administration in 2011. Victrelis is an inhibitor of the non-structural protein 3 (NS3) serine protease. The medication inhibits viral replication in Hepatitis C virus infected cells. | + | Victrelis (boceprevir) is an antiviral Hepatitis C medication approved by the United States Food and Drug Administration in 2011. Victrelis is an inhibitor of the non-structural protein 3 (NS3) serine protease. The medication inhibits viral replication in Hepatitis C virus infected cells.<ref>Merck & Co., Inc. (n.d.) Highlights of prescribing information. Retrieved from https://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.pdf</ref> |
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | This is a default text for your page '''Bailey Dove/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| - | == | + | == Structure of Victrelis == |
| + | The active ingredient in Victrelis, boceprevir, is an equal mixture of two diastereomers made of entirely organic molecules. The molecular formula is C27H45N5O5, and the molecular weight is 519.8 grams/mole. The structural formula is as follows:<ref>Merck & Co., Inc. (n.d.) Highlights of prescribing information. Retrieved from https://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.pdf</ref> | ||
== Disease == | == Disease == | ||
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<ref>Centers for Disease Control and Prevention. (2015). Viral hepatitis - hepatitis C information. Retrieved from http://www.cdc.gov/hepatitis/hcv/index.htm</ref> | <ref>Centers for Disease Control and Prevention. (2015). Viral hepatitis - hepatitis C information. Retrieved from http://www.cdc.gov/hepatitis/hcv/index.htm</ref> | ||
<ref>PMID: 21250386</ref> | <ref>PMID: 21250386</ref> | ||
| + | <ref>PMID: 21250386</ref>Merck & Co., Inc. (n.d.) Highlights of prescribing information. Retrieved from https://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.pdf</ref> | ||
Revision as of 21:16, 11 November 2016
Hepatitis C
The Hepatitis C virus (HCV) is a blood-borne, single stranded RNA virus. [1] The genome of HCV encodes a polyprotein precursor of approximatley 3,000 amino acids, which are cleaved into 1 proteins by various proteases, one of which is the NS3 serine protease. [2]
Victrelis
Victrelis (boceprevir) is an antiviral Hepatitis C medication approved by the United States Food and Drug Administration in 2011. Victrelis is an inhibitor of the non-structural protein 3 (NS3) serine protease. The medication inhibits viral replication in Hepatitis C virus infected cells.[3]
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References
- ↑ Centers for Disease Control and Prevention. (2015). Viral hepatitis - hepatitis C information. Retrieved from http://www.cdc.gov/hepatitis/hcv/index.htm
- ↑ Lin C. HCV NS3-4A Serine Protease PMID:21250386
- ↑ Merck & Co., Inc. (n.d.) Highlights of prescribing information. Retrieved from https://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.pdf
- ↑ Merck & Co., Inc. (n.d.) Highlights of prescribing information. Retrieved from https://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.pdf
[1] [2] [3]Merck & Co., Inc. (n.d.) Highlights of prescribing information. Retrieved from https://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.pdf</ref>
