Aldose Reductase

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**[[3lbo]], [[3ld5]], [[3lql]], [[3lz5]], [[2pdc]], [[3lep]], [[3lqg]], [[3lz3]], [[3m4h]], [[2pdj]], [[2pdp]], [[2pdu]], [[3m64]], [[3mc5]] - hAldR (mutant)+IDD inhibitors<br />
**[[3lbo]], [[3ld5]], [[3lql]], [[3lz5]], [[2pdc]], [[3lep]], [[3lqg]], [[3lz3]], [[3m4h]], [[2pdj]], [[2pdp]], [[2pdu]], [[3m64]], [[3mc5]] - hAldR (mutant)+IDD inhibitors<br />
**[[3dn5]] – hAldR+NADP+biaryl inhibitor<br />
**[[3dn5]] – hAldR+NADP+biaryl inhibitor<br />
-
**[[3v9q]] - hAldR+NADP+ phenol derivative<br />
+
**[[4gq0]] - hAldR+NADP+ phenol derivative<br />
**[[3rx2]], [[3rx3]], [[3rx4]], [[3s3g]] - hAldR+NADP+ sulindac inhibitor<br />
**[[3rx2]], [[3rx3]], [[3rx4]], [[3s3g]] - hAldR+NADP+ sulindac inhibitor<br />
**[[4igs]] - hAldR+NADP+ polyfluorinated inhibitor<br />
**[[4igs]] - hAldR+NADP+ polyfluorinated inhibitor<br />

Revision as of 10:57, 13 November 2016

Human aldose reductase complex with cofactor NADP (PDB code 1ads)

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3D Structures of Aldose Reductase

Updated on 13-November-2016

References

  1. Rondeau JM, Tete-Favier F, Podjarny A, Reymann JM, Barth P, Biellmann JF, Moras D. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Nature. 1992 Jan 30;355(6359):469-72. PMID:1734286 doi:http://dx.doi.org/10.1038/355469a0
  2. Wilson DK, Bohren KM, Gabbay KH, Quiocho FA. An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science. 1992 Jul 3;257(5066):81-4. PMID:1621098

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Michal Harel, Alexander Berchansky

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