Histone
From Proteopedia
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| - | {{STRUCTURE_2hue| PDB=2hue | SIZE= | + | {{STRUCTURE_2hue| PDB=2hue | SIZE=350| SCENE= |right|CAPTION=Yeast H3 (green), H4 (pink) and anti-silencing protein (grey) complex with sulfate, glycerol and Zn+2 ion (grey), [[2hue]] }} |
'''Histones''' (H) are the major protein components of chromatin which help to pack the DNA in the nucleosomes. H2A, H2B, H3 and H4 are core histones while H1 and H5 are linker histones<ref>PMID:16209651</ref>. The '''nucleosome''' is the repeated unit of the chromatin consisting of a core which contains 8 histone molecules (two copies of H2A, H2B, H3 and H4) wrapped by ca. 140 base pairs of DNA<ref>PMID:4825889</ref>. The '''chromatin''' is made of nucleosome cores separated by a linker region of upto 80 base pairs of DNA associated with histones H1 and H5.<br /> | '''Histones''' (H) are the major protein components of chromatin which help to pack the DNA in the nucleosomes. H2A, H2B, H3 and H4 are core histones while H1 and H5 are linker histones<ref>PMID:16209651</ref>. The '''nucleosome''' is the repeated unit of the chromatin consisting of a core which contains 8 histone molecules (two copies of H2A, H2B, H3 and H4) wrapped by ca. 140 base pairs of DNA<ref>PMID:4825889</ref>. The '''chromatin''' is made of nucleosome cores separated by a linker region of upto 80 base pairs of DNA associated with histones H1 and H5.<br /> | ||
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**[[1eqz]] - cH3 + H4 + H2A + H2B + DNA<BR /> | **[[1eqz]] - cH3 + H4 + H2A + H2B + DNA<BR /> | ||
**[[2pyo]], [[2nqb]], [[3nqb]] - DmH3 + H4 + H2A + H2B + DNA <BR /> | **[[2pyo]], [[2nqb]], [[3nqb]] - DmH3 + H4 + H2A + H2B + DNA <BR /> | ||
| - | **[[ | + | **[[4x23]] - DmH3 + H4 + H2A + H2B + centromeric protein C + DNA<br /> |
**[[1u35]] - mH3.1 + H2A + H2B + His2A macro domain + DNA – mouse<BR /> | **[[1u35]] - mH3.1 + H2A + H2B + His2A macro domain + DNA – mouse<BR /> | ||
**[[1f66]] - XlH3 + mH4 + hH2A + XlH2B + DNA<BR /> | **[[1f66]] - XlH3 + mH4 + hH2A + XlH2B + DNA<BR /> | ||
Revision as of 09:53, 17 November 2016
Histones (H) are the major protein components of chromatin which help to pack the DNA in the nucleosomes. H2A, H2B, H3 and H4 are core histones while H1 and H5 are linker histones[1]. The nucleosome is the repeated unit of the chromatin consisting of a core which contains 8 histone molecules (two copies of H2A, H2B, H3 and H4) wrapped by ca. 140 base pairs of DNA[2]. The chromatin is made of nucleosome cores separated by a linker region of upto 80 base pairs of DNA associated with histones H1 and H5.
- For the hyperthermophilic histones see Archaeal Histones.
- For nucleosome structure see User:Eric Martz/Nucleosomes, Nucleosome structure and Nucleosomes.
3D Structures of histone
Updated on 17-November-2016
References
- ↑ Marino-Ramirez L, Kann MG, Shoemaker BA, Landsman D. Histone structure and nucleosome stability. Expert Rev Proteomics. 2005 Oct;2(5):719-29. PMID:16209651 doi:http://dx.doi.org/10.1586/14789450.2.5.719
- ↑ Kornberg RD. Chromatin structure: a repeating unit of histones and DNA. Science. 1974 May 24;184(4139):868-71. PMID:4825889
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