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Ribozyme

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<Structure load='379d' size='400' scene='Ribozyme/Cv/3' frame='true' align='right' caption='Hammerhead ribozyme, [[379d]]'/>
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<Structure load='379d' size='350' scene='Ribozyme/Cv/3' frame='true' align='right' caption='Hammerhead ribozyme, [[379d]]'/>
[[Ribozyme]] (RZ) is an RNA molecule which catalyzes a chemical reaction<ref>PMID:9224568</ref>.<br />
[[Ribozyme]] (RZ) is an RNA molecule which catalyzes a chemical reaction<ref>PMID:9224568</ref>.<br />
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**[[1vc5]], [[4prf]] - HDVRZ + U1 small nuclear ribonucleoprotein A (mutant) <BR />
**[[1vc5]], [[4prf]] - HDVRZ + U1 small nuclear ribonucleoprotein A (mutant) <BR />
**[[2oj3]], [[1sj3]], [[1sj4]], [[1sjf]], [[1vbx]], [[1vby]], [[1vbz]], [[1vc0]] - HDVRZ (mutant) + U1 small nuclear ribonucleoprotein A<BR />
**[[2oj3]], [[1sj3]], [[1sj4]], [[1sjf]], [[1vbx]], [[1vby]], [[1vbz]], [[1vc0]] - HDVRZ (mutant) + U1 small nuclear ribonucleoprotein A<BR />
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**[[1vc6]], [[1vc7]], [[1cx0]], [[1drz]]- HDVRZ (mutant) + U1 small nuclear ribonucleoprotein A (mutant)
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**[[1vc6]], [[4prf]], [[1cx0]], [[1drz]]- HDVRZ (mutant) + U1 small nuclear ribonucleoprotein A (mutant)
*glmS ribozyme
*glmS ribozyme

Revision as of 11:27, 17 November 2016

Hammerhead ribozyme, 379d

Drag the structure with the mouse to rotate

Ribozyme (RZ) is an RNA molecule which catalyzes a chemical reaction[1].

  • Glucosamine-6-phosphate activated RZ (glmS RZ) is a RZ and a riboswitch which regulates genes in response to metabolites.
  • Leadzyme is a small, artificially-made RZ which can cleave RNA in the presence of lead. For more details on leadzyme see Student Projects for UMass Chemistry 423 Spring 2012-10.
  • Hairpin RZ and hammerhead RZ are named based on their shape[2].
  • Group I intron catalyzes its own selfish splicing[3].
  • Comparative genomic analysis revealed Twister, Twister sister, Hatchet, and Pistol [4][5].


Articles in Proteopedia concerning ribozymes include:


To view automatically seeded indices concerning ribozymes, see:

3D Structures of Ribozymes

Updated on 17-November-2016


References

  1. ↑ Tang J, Breaker RR. Rational design of allosteric ribozymes. Chem Biol. 1997 Jun;4(6):453-9. PMID:9224568
  2. ↑ Amarzguioui M, Prydz H. Hammerhead ribozyme design and application. Cell Mol Life Sci. 1998 Nov;54(11):1175-202. PMID:9849614 doi:http://dx.doi.org/10.1007/s000180050247
  3. ↑ Cech TR. Self-splicing of group I introns. Annu Rev Biochem. 1990;59:543-68. PMID:2197983 doi:http://dx.doi.org/10.1146/annurev.bi.59.070190.002551
  4. ↑ Roth A, Weinberg Z, Chen AG, Kim PB, Ames TD, Breaker RR. A widespread self-cleaving ribozyme class is revealed by bioinformatics. Nat Chem Biol. 2014 Jan;10(1):56-60. doi: 10.1038/nchembio.1386. Epub 2013 Nov, 17. PMID:24240507 doi:http://dx.doi.org/10.1038/nchembio.1386
  5. ↑ Weinberg Z, Kim PB, Chen TH, Li S, Harris KA, Lunse CE, Breaker RR. New classes of self-cleaving ribozymes revealed by comparative genomics analysis. Nat Chem Biol. 2015 Aug;11(8):606-10. doi: 10.1038/nchembio.1846. Epub 2015 Jul, 13. PMID:26167874 doi:http://dx.doi.org/10.1038/nchembio.1846

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