Ribozyme
From Proteopedia
(Difference between revisions)
| Line 41: | Line 41: | ||
**[[3nkb]] – HDVRZ + DNA/RNA – Hepatitis delta virus<BR /> | **[[3nkb]] – HDVRZ + DNA/RNA – Hepatitis delta virus<BR /> | ||
| + | **[[4prf]] – HDVRZ<br /> | ||
**[[1ato]] – HDVRZ - NMR<BR /> | **[[1ato]] – HDVRZ - NMR<BR /> | ||
**[[2oih]], [[4pr6]] - HDVRZ + U1 small nuclear ribonucleoprotein A<BR /> | **[[2oih]], [[4pr6]] - HDVRZ + U1 small nuclear ribonucleoprotein A<BR /> | ||
**[[1vc5]], [[4prf]] - HDVRZ + U1 small nuclear ribonucleoprotein A (mutant) <BR /> | **[[1vc5]], [[4prf]] - HDVRZ + U1 small nuclear ribonucleoprotein A (mutant) <BR /> | ||
**[[2oj3]], [[1sj3]], [[1sj4]], [[1sjf]], [[1vbx]], [[1vby]], [[1vbz]], [[1vc0]] - HDVRZ (mutant) + U1 small nuclear ribonucleoprotein A<BR /> | **[[2oj3]], [[1sj3]], [[1sj4]], [[1sjf]], [[1vbx]], [[1vby]], [[1vbz]], [[1vc0]] - HDVRZ (mutant) + U1 small nuclear ribonucleoprotein A<BR /> | ||
| - | **[[1vc6]], [[4prf]], [[ | + | **[[1vc6]], [[4prf]], [[1pr6]], [[1drz]]- HDVRZ (mutant) + U1 small nuclear ribonucleoprotein A (mutant) |
*glmS ribozyme | *glmS ribozyme | ||
| Line 62: | Line 63: | ||
**[[3gs1]], [[3gs5]], [[3gs8]], [[2bcy]], [[2bcz]], [[2fgp]], [[1x9c]], [[1x9k]] - Hairpin RZ (mutant) <BR /> | **[[3gs1]], [[3gs5]], [[3gs8]], [[2bcy]], [[2bcz]], [[2fgp]], [[1x9c]], [[1x9k]] - Hairpin RZ (mutant) <BR /> | ||
**[[3cr1]] – Hairpin RZ + RNA<BR /> | **[[3cr1]] – Hairpin RZ + RNA<BR /> | ||
| - | **[[ | + | **[[2m24]], [[2m23]], [[2k65]], [[2k66]] - Hairpin RZ 29-mer – NMR<BR /> |
**[[3b58]], [[3b5a]], [[3b5f]], [[3b5s]], [[3b91]], [[3bbi]], [[3bbk]], [[3bbm]] - Hairpin RZ 29-mer + RNA<BR /> | **[[3b58]], [[3b5a]], [[3b5f]], [[3b5s]], [[3b91]], [[3bbi]], [[3bbk]], [[3bbm]] - Hairpin RZ 29-mer + RNA<BR /> | ||
**[[2npy]], [[2npz]] - Hairpin RZ + RZ domain linking strand<BR /> | **[[2npy]], [[2npz]] - Hairpin RZ + RZ domain linking strand<BR /> | ||
| Line 75: | Line 76: | ||
**[[3czw]], [[3d0m]] - Hammerhead RZ shorter strands<BR /> | **[[3czw]], [[3d0m]] - Hammerhead RZ shorter strands<BR /> | ||
**[[2qus]], [[2quw]] - Hammerhead RZ (mutant) <BR /> | **[[2qus]], [[2quw]] - Hammerhead RZ (mutant) <BR /> | ||
| - | **[[2oeu | + | **[[2oeu]] - Hammerhead RZ + RNA<br /> |
**[[488d]] – Hammerhead RZ + RNA products<br /> | **[[488d]] – Hammerhead RZ + RNA products<br /> | ||
| - | ** | + | **[[3zd5]], [[3zp8]] - Hammerhead RZ enzyme+substrate strands<br /> |
**[[3zd4]] - Hammerhead RZ enzyme strand | **[[3zd4]] - Hammerhead RZ enzyme strand | ||
Revision as of 10:44, 24 November 2016
|
Ribozyme (RZ) is an RNA molecule which catalyzes a chemical reaction[1].
- Glucosamine-6-phosphate activated RZ (glmS RZ) is a RZ and a riboswitch which regulates genes in response to metabolites.
- Leadzyme is a small, artificially-made RZ which can cleave RNA in the presence of lead. For more details on leadzyme see Student Projects for UMass Chemistry 423 Spring 2012-10.
- Hairpin RZ and hammerhead RZ are named based on their shape[2].
- Group I intron catalyzes its own selfish splicing[3].
- Comparative genomic analysis revealed Twister, Twister sister, Hatchet, and Pistol [4][5].
Articles in Proteopedia concerning ribozymes include:
- Azoarcus group I intron
- Kink-turn motif
- Ribosome
- The Large Ribosomal Subunit
- Hairpin Ribozyme
- Human CPEB3 ribozyme's P4 domain
To view automatically seeded indices concerning ribozymes, see:
- Ribozyme
- Catalytic RNA
- GlmS
- Hammerhead
- Hairpin
- Hepatitis delta virus
- Twister
- Twister sister
- Hatchet
- Pistol
- Group I intron
- Varkud satellite
3D Structures of Ribozymes
Updated on 24-November-2016
References
- ↑ Tang J, Breaker RR. Rational design of allosteric ribozymes. Chem Biol. 1997 Jun;4(6):453-9. PMID:9224568
- ↑ Amarzguioui M, Prydz H. Hammerhead ribozyme design and application. Cell Mol Life Sci. 1998 Nov;54(11):1175-202. PMID:9849614 doi:http://dx.doi.org/10.1007/s000180050247
- ↑ Cech TR. Self-splicing of group I introns. Annu Rev Biochem. 1990;59:543-68. PMID:2197983 doi:http://dx.doi.org/10.1146/annurev.bi.59.070190.002551
- ↑ Roth A, Weinberg Z, Chen AG, Kim PB, Ames TD, Breaker RR. A widespread self-cleaving ribozyme class is revealed by bioinformatics. Nat Chem Biol. 2014 Jan;10(1):56-60. doi: 10.1038/nchembio.1386. Epub 2013 Nov, 17. PMID:24240507 doi:http://dx.doi.org/10.1038/nchembio.1386
- ↑ Weinberg Z, Kim PB, Chen TH, Li S, Harris KA, Lunse CE, Breaker RR. New classes of self-cleaving ribozymes revealed by comparative genomics analysis. Nat Chem Biol. 2015 Aug;11(8):606-10. doi: 10.1038/nchembio.1846. Epub 2015 Jul, 13. PMID:26167874 doi:http://dx.doi.org/10.1038/nchembio.1846
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Wayne Decatur, Joel L. Sussman, Alexander Berchansky
