User:Megan Harris./Sandbox 1

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== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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</StructureSection>
</StructureSection>

Revision as of 00:15, 27 November 2016

Grazoprevir, a NS3/4A serine protease inhibitor. PDB: 5EPY

Drag the structure with the mouse to rotate

References

  1. Soumana DI, Kurt Yilmaz N, Prachanronarong KL, Aydin C, Ali A, Schiffer CA. Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172. ACS Chem Biol. 2015 Dec 18. PMID:26682473 doi:http://dx.doi.org/10.1021/acschembio.5b00647
  2. Coburn CA, Meinke PT, Chang W, Fandozzi CM, Graham DJ, Hu B, Huang Q, Kargman S, Kozlowski J, Liu R, McCauley JA, Nomeir AA, Soll RM, Vacca JP, Wang D, Wu H, Zhong B, Olsen DB, Ludmerer SW. Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity. ChemMedChem. 2013 Dec;8(12):1930-40. doi: 10.1002/cmdc.201300343. Epub 2013 Oct, 14. PMID:24127258 doi:http://dx.doi.org/10.1002/cmdc.201300343
  3. National Center for Biotechnology Inforamtion. PubChem Compound Database; CID=71661251, https://pubchem.ncbi.nlm.nih.gov/compound/71661251#section=Chemical-and-Physical-Properties
  4. doi: https://dx.doi.org/http
  5. Fridell RA, Qiu D, Valera L, Wang C, Rose RE, Gao M. Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052. J Virol. 2011 Jul;85(14):7312-20. doi: 10.1128/JVI.00253-11. Epub 2011 May 18. PMID:21593143 doi:http://dx.doi.org/10.1128/JVI.00253-11
  6. National Center for Biotechnology Information. PubChem Compound Database; CID=44603531, https://pubchem.ncbi.nlm.nih.gov/compound/44603531.
  7. Soumana DI, Kurt Yilmaz N, Prachanronarong KL, Aydin C, Ali A, Schiffer CA. Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172. ACS Chem Biol. 2015 Dec 18. PMID:26682473 doi:http://dx.doi.org/10.1021/acschembio.5b00647
  8. Chevaliez, S.; Pawlotsky, J. M. Virology of hepatitis C virus infection. Best Pract. Res. Clin. Gastroenterol.2012, 26, 381-389.
  9. Petrescu, I. O.; Biciusca, V.; Taisescu, C. I.; Alexandru, D. O.; Taisescu, O.; Comanescu, M. V.; Petrescu, F.; Popescu, I. A.; Trasca, D. M.; ForTofoiu, M. C.; Silosi, C. A.; ForTofoiu, M. Histological factors that predict the liver fibrosis in patients with chronic hepatitis C. Rom. J. Morphol. Embryol. 2016, 57, 759-765.

[1] [2] [3] [4] [5] [6] [7] [8]

Proteopedia Page Contributors and Editors (what is this?)

Megan Harris.

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