GTP-binding protein

From Proteopedia

(Difference between revisions)

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 *'''Small GTPase h-Ras''' see [[GTPase HRas]]
-*'''Heterotrimeric G protein'''
+*'''Heterotrimeric G protein see [[Transducin]]'''
-*GNBP α subunit
-**[[1gia]], [[1gil]] – rGNBP + GSP – rat <br />
-**[[1gfi]], [[1gdd]], [[1bof]] – rGNBP + GDP  <br />
-**[[1cip]], [[1svs]] – rGNBP + GNP  <br />
-**[[1git]], [[1as3]], [[1svk]], [[3d7m]], [[2zjy]], [[2zjz]], [[3ffb]], [[4n0e]] – rGNBP (mutant) + GDP  <br />
-**[[1bh2]], [[3ffa]] – rGNBP (mutant) + GSP  <br />
-**[[3ums]], [[3umr]] – hGNBP (mutant) + GDP - human <br />
-**[[1as0]], [[4n0d]] – rGNBP (mutant) + GTPγS  <br />
-**[[1as2]] – rGNBP (mutant) + GDP + Pi<br />
-**[[3v00]] – rGNBP/bGNBP (mutant) + GDP  <br />
-**[[2xtz]] - GNBP + GDP derivative – ''Arabidopsis thaliana'' <br />
-*GNBP α subunit complex with protein
-**[[1agr]] – rGNBP + GDP  + regulator of G protein signalling<br />
-**[[1kjy]], [[2gtp]], [[2ik8]], [[2om2]], [[4g5q]], [[2ihb]], [[2ode]], [[2v4z]], [[3onw]] – hGNBP + GDP  + regulator of G protein signaling <br />
-**[[2om2]] – hGNBP (mutant) + GDP  + regulator of G protein signaling <br />
-**[[2xns]] – hGNBP + GDP  + regulator of G protein signaling peptide<br />
-**[[3qi2]] – hGNBP (mutant) + GDP  + regulator of G protein signaling peptide<br />
-**[[4g5o]], [[4g5r]], [[4g5s]] – hGNBP (mutant) + GDP  + G protein signaling modulator<br />
-**[[1shz]] – rGNBP/mGNBP + GDP  + ρ guanine nucleotide exchange factor<br />
-**[[1y3a]] – rGNBP + GDP  + Kb752 peptide<br />
-**[[3qe0]] – hGNBP (mutant) + GDP  + Kb752 peptide<br />
-**[[2g83]] – hGNBP + GDP  + Kb1753 peptide<br />
-**[[4g5o]], [[4g5r]], [[4g5s]] – hGNBP (mutant) + GDP  + G protein signaling modulator<br />
-**[[1cjk]], [[1cjt]], [[1cju]], [[1cjv]], [[1cs4]], [[1cul]] – hGNBP (mutant) + GTP derivative + adenylate cyclase<br />
-**[[1u0h]] – hGNBP + GTP derivative + adenylate cyclase<br />
-**[[2gvd]], [[2gvz]], [[3maa]] – bGNBP + ATP derivative + adenylate cyclase<br />
-**[[3g82]] – bGNBP + ITP derivative + adenylate cyclase<br />
-**[[3c14]], [[3c15]], [[3c16]] – bGNBP + PPi + adenylate cyclase<br />
-**[[1tl7]] – bGNBP (mutant) + GTP derivative + adenylate cyclase<br />
-**[[2rgn]] – mGNBP + RHOA exchange factor + transforming protein RHOA – mouse<br />
-**[[3cx8]] – mGNBP + GTP + RHOA exchange factor <br />
-**[[3c7k]] – mGNBP + GDP + regulator of G protein signaling <br />
-**[[4ekc]], [[4ekd]] – mGNBP (mutant) + GDP + regulator of G protein signaling <br />
-**[[3ohm]], [[4gnk]] – mGNBP + GDP + phospholipase C <br />
-*GNBP β subunit
-**[[2pbi]] – mGNBP + regulator of G protein signaling <br />
-*GNBP β+γ subunits
-**[[1omw]] – bGNBP + G protein coupled receptor kinase <br />
-**[[3v5w]] – bGNBP (mutant) + G protein coupled receptor kinase <br />
-**[[1xhm]] – bGNBP + peptide<br />
-**[[3krw]], [[3krx]] – bGNBP + balanol + β-adrenergic receptor kinase<br />
-**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bGNBP + β-adrenergic receptor kinase<br />
-**[[3uzs]] – bGNBP + RNA + β-adrenergic receptor kinase<br />
-**[[4kfm]] – hGNBP + inward rectifier K+ channel<br />
-*GNBP α+β+γ subunits
-**[[1gg2]], [[1gp2]] – rGNBP (mutant) + GDP  <br />
-**[[1shz]] – rGNBP/mGNBP (mutant)+ GDP  + inhibitor<br />
-**[[2bcj]] – bGNBP (mutant) + G protein coupled receptor kinase <br />
-**[[3sn6]] – bGNBP (mutant) + lysozyme <br />
 }}

Revision as of 07:54, 28 November 2016

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E. coli small GTP-binding protein ERA complex with GDP and sulfate (PDB code 3ieu)

Show:Asymmetric Unit Biological Assembly

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1 Function
2 Disease
3 Structural highlights

Function

GTP-binding proteins or G proteins are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: heterotrimeric G proteins^[1] and small GTPases^[2]. The structure of small GTPase is homologous to that of the α subunit of heterotrimeric G protein. See details on small GTP-binding protein LepA in LepA.

Heterotrimeric G protein or guanine nucleotide-binding protein or G protein (GNBP) are heterodimeric membrane proteins composed of α, β and γ subunits. GNBP is involved in mammalian cellular signaling pathways. GNBP α subunit binds GDP or GTP. When bound to GTP it dissociates from the β and γ subunits, binds to adenylate cyclase which converts ATP to cAMP. See also

G protein-coupled receptor
Beta2 adrenergic receptor-Gs protein complex.

Disease

Mutations in heterotrimeric G protein α subunit were identified in endocrine tumors and in McCune-Albright syndrome^[3].

Structural highlights

E. coli small GTPase ERA binds GDP in a cavity formed by ^[4]. . Water molecules shown as red spheres.

3D Structures of GTP-binding protein

Updated on 28-November-2016

References

↑ Preininger AM, Hamm HE. G protein signaling: insights from new structures. Sci STKE. 2004 Jan 27;2004(218):re3. PMID:14762218 doi:http://dx.doi.org/10.1126/stke.2182004re3
↑ Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins. Physiol Rev. 2001 Jan;81(1):153-208. PMID:11152757
↑ Lania A, Mantovani G, Spada A. G protein mutations in endocrine diseases. Eur J Endocrinol. 2001 Nov;145(5):543-59. PMID:11720871
↑ Tu C, Zhou X, Tropea JE, Austin BP, Waugh DS, Court DL, Ji X. Structure of ERA in complex with the 3' end of 16S rRNA: implications for ribosome biogenesis. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14843-8. Epub 2009 Aug 17. PMID:19706445