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Ubiquitin

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- 
<StructureSection load='3k9p' size='340' side='right' caption='Human ubiquitin (green) complex with ubiquitin-conjugating enzyme E2 (grey), [[3k9p]]' scene='' >
<StructureSection load='3k9p' size='340' side='right' caption='Human ubiquitin (green) complex with ubiquitin-conjugating enzyme E2 (grey), [[3k9p]]' scene='' >
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**[[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]], [[2kox]], [[2ld9]], [[2k25]] – hUBB – NMR - human<br />
**[[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]], [[2kox]], [[2ld9]], [[2k25]] – hUBB – NMR - human<br />
-
**[[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]], [[1xqq]], [[3ons]], [[4wzp]] - hUBB<br />
+
**[[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]], [[1xqq]], [[3ons]], [[4wzp]], [[5k9p]], [[4zqs]], [[5dk8]], [[4xof]], [[4xok]], [[4xol]], [[4zpz]] - hUBB<br />
**[[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]], [[4hk2]], [[4hjk]], [[4pij]], [[4pih]], [[4pig]] - hUBB (mutant)<br />
**[[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]], [[4hk2]], [[4hjk]], [[4pij]], [[4pih]], [[4pig]] - hUBB (mutant)<br />
**[[1c3t]], [[1ud7]], [[2mi8]], [[2rsu]], [[2ru6]] - hUBB (mutant) - NMR<br />
**[[1c3t]], [[1ud7]], [[2mi8]], [[2rsu]], [[2ru6]] - hUBB (mutant) - NMR<br />
Line 36: Line 35:
**[[1cmx]] – yUBB (modified)<br />
**[[1cmx]] – yUBB (modified)<br />
**[[2zcc]] – bUBB - bovine<br />
**[[2zcc]] – bUBB - bovine<br />
- 
-
* Ubiquitin+UBB-activating enzymes
 
- 
-
**[[3cmm]] – yUBB+E1 <br />
 
-
**[[3k9p]], [[3a33]] – hUBB+E2<br />
 
-
**[[2gmi]] - hUBB+E2+MMS2<br />
 
-
**[[2kjh]], [[1zgu]] – hUBB (mutant)+E2<br />
 
-
**[[3jvz]], [[3jw0]] – hUBB+E2+E3<br />
 
* Ubiquitin+1 mutant
* Ubiquitin+1 mutant
Line 52: Line 43:
* Ubiquitin dimer
* Ubiquitin dimer
-
**[[2xk5]], [[3nob]], [[2xew]], [[3h7p]], [[3h7s]], [[2w9n]], [[2jf5]], [[3ns8]], [[3aul]], [[3axc]] – hDiUBB<br />
+
**[[2xk5]], [[3nob]], [[2xew]], [[3h7p]], [[3h7s]], [[2w9n]], [[2jf5]], [[3ns8]], [[3aul]], [[3axc]], [[5gob]], [[5goc]], [[5god]], [[5gog]], [[5goh]], [[5goi]], [[5goj]], [[5j8p]] – hDiUBB<br />
 +
]], [[5goi]], [[5goj]], [[5j8p]] – hDiUBB<br />
**[[2mbo]], [[2mbq]] – hDiUBB – NMR<br />
**[[2mbo]], [[2mbq]] – hDiUBB – NMR<br />
**[[3m3j]], [[1aar]], [[3aui]] – bDiUBB <br />
**[[3m3j]], [[1aar]], [[3aui]] – bDiUBB <br />
Line 74: Line 66:
**[[4bos]] – hDiUBB + UBB thiolesterase + OTUD2<br />
**[[4bos]] – hDiUBB + UBB thiolesterase + OTUD2<br />
**[[4s1z]] – hDiUBB + ZranB1<br />
**[[4s1z]] – hDiUBB + ZranB1<br />
 +
**[[5e6j]] – hDiUBB (mutant) + replicase polyprotein<br />
 +
**[[2n13]] – hDiUBB + myosin peptide - NMR<br />
 +
**[[3wwq]] – hDiUBB + FAAP20 peptide <br />
* Ubiquitin trimer
* Ubiquitin trimer
 +
**[[5go7]], [[5gok]], [[5jby]], [[5jbv]] – hTriUBB <br />
**[[3zlz]] – hTriUBB (mutant) <br />
**[[3zlz]] – hTriUBB (mutant) <br />
**[[4boz]] – hTriUBB + UBB thiolesterase <br />
**[[4boz]] – hTriUBB + UBB thiolesterase <br />
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* Ubiquitin tetramer
* Ubiquitin tetramer
 +
**[[5go8]] – hTetraUBB <br />
**[[3tmp]] – hTetraUBB + deubiquitinase<br />
**[[3tmp]] – hTetraUBB + deubiquitinase<br />
**[[3alb]], [[3hm3]], [[2o6v]], [[1f9j]], [[1tbe]] – tetra-hUBB<br />
**[[3alb]], [[3hm3]], [[2o6v]], [[1f9j]], [[1tbe]] – tetra-hUBB<br />
**[[3zni]] – hTetraUBB + E3 UBB protein ligase + tyrosine protein kinase + UBB conjugating enzyme E2<br />
**[[3zni]] – hTetraUBB + E3 UBB protein ligase + tyrosine protein kinase + UBB conjugating enzyme E2<br />
 +
**[[5b83]] – hTetraUBB + optineurin<br />
* Ubiquitin monomer bound to protein
* Ubiquitin monomer bound to protein
**[[3ofi]] – hUBB+insulin protease
**[[3ofi]] – hUBB+insulin protease
-
**[[3n3k]], [[3ifw]], [[3kvf]], [[3kw5]], [[3irt]], [[3mtn]], [[3ihp]], [[3v6c]], [[3v6e]– hUBB (mutant)+hUBB carboxyl-terminal esterase catalytic domain<br />
+
**[[3n3k]], [[3ifw]], [[3kvf]], [[3kw5]], [[3irt]], [[3mtn]], [[3ihp]], [[3v6c]], [[3v6e]]– hUBB (mutant)+hUBB carboxyl-terminal esterase catalytic domain<br />
-
**[[3i3t]], [[2ibi]], [[2ayo]], [[1nbf]], [[2wdt]], [[4i6l]], [[4i6n]], [[4ig7]] - hUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br />
+
**[[3i3t]], [[2ibi]], [[2ayo]], [[1nbf]], [[2wdt]], [[4i6l]], [[4i6n]], [[4ig7]], [[5l8h]], [[5jtj]], [[5cvm]] - hUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br />
 +
**[[5l8w]], [[5cvn]], [[5cvo]] – hUBB + UBB carboxy terminal hydrolase 12 + WD repeat containing protein 48<br />
**[[2khw]] – hUBB+immunoglobulin G-binding protein G<br />
**[[2khw]] – hUBB+immunoglobulin G-binding protein G<br />
**[[1yx5]], [[1yx6]] - hUBB+26S proteasome non-ATPase regulatory subunit – NMR<br />
**[[1yx5]], [[1yx6]] - hUBB+26S proteasome non-ATPase regulatory subunit – NMR<br />
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**[[3pt2]] – hUBB+RNA polymerase OTU domain<br />
**[[3pt2]] – hUBB+RNA polymerase OTU domain<br />
**[[2rr9]] – hUBB + Uimc1<br />
**[[2rr9]] – hUBB + Uimc1<br />
-
**[[1fxt]], [[3oj4]], [[3ugb]] – hUBB + UBB conjugating enzyme E2<br />
+
**[[1fxt]], [[3oj4]], [[3ugb]], [[5dfl]], [[3k9p]], [[3a33]] – hUBB + UBB conjugating enzyme E2<br />
**[[2fuh]] – hUBB + UBB conjugating enzyme E2 - NMR<br />
**[[2fuh]] – hUBB + UBB conjugating enzyme E2 - NMR<br />
**[[4auq]] – hUBB + UBB conjugating enzyme E2 + livin<br />
**[[4auq]] – hUBB + UBB conjugating enzyme E2 + livin<br />
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**[[4un2]] – hUBB + Dsk2 peptide<br />
**[[4un2]] – hUBB + Dsk2 peptide<br />
**[[4msq]], [[4msm]] – hUBB + AMSH-like protease<br />
**[[4msq]], [[4msm]] – hUBB + AMSH-like protease<br />
 +
**[[5ln1]] – hUBB + RPN10<br />
 +
**[[5jp3]] – hUBB + xanthomonas outer protein<br />
 +
**[[5lrw]] – hUBB (mutant)+ OUT domain containing protein 7B<br />
 +
**[[5lrx]] – hUBB (mutant)+ OUT domain containing protein 7C<br />
 +
**[[5kgf]] – hUBB + nucleosome<br />
 +
**[[2nbv]] – hUBB + proteasomal UBB receptor - NMR<br />
 +
**[[5jg6]] – hUBB + anaphase promoting complex subunit 11<br />
**[[5af6]] – hUBB + TRABID<br />
**[[5af6]] – hUBB + TRABID<br />
**[[4un2]] – hUBB + Dsk2 peptide<br />
**[[4un2]] – hUBB + Dsk2 peptide<br />
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**[[4q5h]], [[4q5e]] – yUBB + UBB conjugating enzyme E2 + OspG<br />
**[[4q5h]], [[4q5e]] – yUBB + UBB conjugating enzyme E2 + OspG<br />
**[[4nql]] – mUBB + AMSH-like protease<br />
**[[4nql]] – mUBB + AMSH-like protease<br />
 +
 +
* Ubiquitin complex with ubiquitination enzymes
 +
 +
**[[1fxt]], [[3oj4]], [[3ugb]], [[5dfl]], [[3k9p]], [[3a33]] – hUBB + UBB conjugating enzyme E2<br />
 +
**[[5bnb]], [[2kjh]], [[1zgu]] – hUBB (mutant) + UBB conjugating enzyme E2<br />
 +
**[[5edv]], [[4whv]], [[5ait]], [[5aiu]], [[3jvz]], [[3jw0]] – hUBB + UBB conjugating enzyme E2 + E3 UBB-protein ligase<br />
 +
**[[3cmm]] – yUBB + UBB activating enzyme E1<br />
 +
**[[2gmi]] – hUBB + UBB conjugating enzyme E2<br />
 +
**[[5d0k]], [[5d0m]] – hUBB + UBB conjugating enzyme E2 + ring finger protein 165<br />
 +
**[[4xkl]] – hUBB + NDP52<br />
 +
**[[4zfr]], [[4zft]] – hUBB + SST2<br />
 +
**[[2fuh]] – hUBB + UBB conjugating enzyme E2 - NMR<br />
 +
**[[4auq]] – hUBB + UBB conjugating enzyme E2 + livin<br />
 +
**[[4q5h]], [[4q5e]] – yUBB + UBB conjugating enzyme E2 + OspG<br />
* Ubiquitin + ions
* Ubiquitin + ions

Revision as of 08:37, 30 November 2016

Human ubiquitin (green) complex with ubiquitin-conjugating enzyme E2 (grey), 3k9p

Drag the structure with the mouse to rotate

3D Structures of Ubiquitin

Updated on 30-November-2016

]], 5goi, 5goj, 5j8p – hDiUBB

References

  1. ↑ Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem. 1998;67:425-79. PMID:9759494 doi:http://dx.doi.org/10.1146/annurev.biochem.67.1.425
  2. ↑ Paul S. Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: therapeutic approaches. Bioessays. 2008 Nov;30(11-12):1172-84. doi: 10.1002/bies.20852. PMID:18937370 doi:http://dx.doi.org/10.1002/bies.20852
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