NitroDur
From Proteopedia
(Difference between revisions)
(New page: ==NitroDur==<scene name='74/745476/Cys-302_of_aldh2/1'></scene> <StructureSection load='' size='340' side='right' scene='74/745476/Humanaldehydedehydrogenase/1'> ==Structure== The main in...) |
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<StructureSection load='' size='340' side='right' scene='74/745476/Humanaldehydedehydrogenase/1'> | <StructureSection load='' size='340' side='right' scene='74/745476/Humanaldehydedehydrogenase/1'> | ||
==Structure== | ==Structure== | ||
| - | The main ingredient of NitroDura is 1,2,3-propanetriol trinitrate, also known as <scene name='74/745476/Nitroglycerinmolecule/3'>Nitroglycerin</scene>. Nitroglycerin is a molecule that when broken down to nitric oxide binds to protein domains found in smooth muscle. These binding domains are often found in the form of dimers that require multiple NO molecules to bind as seen in <scene name='74/745476/2o0c_molecule/3'>Nitric Oxide bound to the domain of Nostoc cyanbacterial protein</scene>. The Nitric Oxide is often buried deep within the protein, that in conjunction with other molecular interactions triggers structural changes that activate proteins to serve their specific functions | + | The main ingredient of NitroDura is 1,2,3-propanetriol trinitrate, also known as <scene name='74/745476/Nitroglycerinmolecule/3'>Nitroglycerin</scene>. Nitroglycerin is a molecule that when broken down to nitric oxide binds to protein domains found in smooth muscle. These binding domains are often found in the form of dimers that require multiple NO molecules to bind as seen in <scene name='74/745476/2o0c_molecule/3'>Nitric Oxide bound to the domain of Nostoc cyanbacterial protein</scene>. The Nitric Oxide is often buried deep within the protein, that in conjunction with other molecular interactions triggers structural changes that activate proteins to serve their specific functions. In humans, NO binds to protein domains in this same fashion, as seen in <scene name='74/745476/Guanylate_cyclase/2'>Heterodimeric Catalytic Domain of Wild-type Human Soluble Guanylate Cyclase </scene>. |
==Medication Details== | ==Medication Details== | ||
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===Raynaud’s Phenomenon=== | ===Raynaud’s Phenomenon=== | ||
The Raynaud's pehnomenon occurs due to vasoconstriction of the capillaries, veins, and arteries in external digits <ref name="citation2"> <ref>PMCID: PMC2860448</ref>. Symptoms of raynaud’s involves the fingers or toes turning pale, becoming numb, and then transitioning to a shade of purple or blue. These symptoms result from attacks that are characterized by spasms in the small blood vessels of the fingers and toes <ref>Haythornthwaite, Jenifer, Dr., and Fredrick Wigley, Dr. "Raynaud's, Finger and Skin Care." Scleroderma Education Program Chapter 2 Raynaud’s, Finger and Skin Care (n.d.): n. pag. Web. 16 Oct. 2016 </ref>. Patients who have been diagnosed with Raynaud’s phenomenon will occasionally need pharmacological therapy. While the nitro-dur patch is not specifically precribe, topical nitroglycerin ointment is used on these patients to decrease the occurrence and severity of vasospastic episodes <ref name="citation2"> </ref>. Nitroglycerin does this by expanding the blood vessels allowing better blood circulation <ref name="citation3"> </ref>. | The Raynaud's pehnomenon occurs due to vasoconstriction of the capillaries, veins, and arteries in external digits <ref name="citation2"> <ref>PMCID: PMC2860448</ref>. Symptoms of raynaud’s involves the fingers or toes turning pale, becoming numb, and then transitioning to a shade of purple or blue. These symptoms result from attacks that are characterized by spasms in the small blood vessels of the fingers and toes <ref>Haythornthwaite, Jenifer, Dr., and Fredrick Wigley, Dr. "Raynaud's, Finger and Skin Care." Scleroderma Education Program Chapter 2 Raynaud’s, Finger and Skin Care (n.d.): n. pag. Web. 16 Oct. 2016 </ref>. Patients who have been diagnosed with Raynaud’s phenomenon will occasionally need pharmacological therapy. While the nitro-dur patch is not specifically precribe, topical nitroglycerin ointment is used on these patients to decrease the occurrence and severity of vasospastic episodes <ref name="citation2"> </ref>. Nitroglycerin does this by expanding the blood vessels allowing better blood circulation <ref name="citation3"> </ref>. | ||
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== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 15:47, 1 December 2016
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