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Undecaprenyl pyrophosphate synthase

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Line 19: Line 19:
**[[1f75]] – UPP (mutant) – ''Micrococcus luteus''<br />
**[[1f75]] – UPP (mutant) – ''Micrococcus luteus''<br />
-
**[[3qas]] – EcUPP – ''Escherichia coli''<br />
+
**[[3qas]], [[5cqb]] – EcUPP – ''Escherichia coli''<br />
**[[1jp3]] – EcUPP (mutant) <br />
**[[1jp3]] – EcUPP (mutant) <br />
**[[2d2r]] – HpUPP (mutant) – ''Helicobacter pylori''<br />
**[[2d2r]] – HpUPP (mutant) – ''Helicobacter pylori''<br />
**[[2vg4]] – MtUPP – ''Mycobacterium tuberculosis''<br />
**[[2vg4]] – MtUPP – ''Mycobacterium tuberculosis''<br />
 +
**[[5kh2]] – SpUPP – ''Streptococcus pneumoniae''<br />
*Undecaprenyl pyrophosphate synthase complexes
*Undecaprenyl pyrophosphate synthase complexes
Line 32: Line 33:
**[[1x07]] – EcUPP + Mg + PO4 + IPP<br />
**[[1x07]] – EcUPP + Mg + PO4 + IPP<br />
**[[1x09]] – EcUPP (mutant) + Mg + IPP<br />
**[[1x09]] – EcUPP (mutant) + Mg + IPP<br />
-
**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]] – EcUPP + bisphosphonate<br />
+
**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br />
 +
**[[5cqj]] – EcUPP + inhibitor <br />
 +
**[[5kh4]] – SpUPP + FPP <br />
 +
**[[5kh5]] – SpUPP + inhibitor <br />
**[[2dtn]] – HpUPP + pyrophosphate<br />
**[[2dtn]] – HpUPP + pyrophosphate<br />
**[[3ugs]] - UPP + FPP analog – ''Campylobacter jejuni''<br />
**[[3ugs]] - UPP + FPP analog – ''Campylobacter jejuni''<br />

Revision as of 08:36, 6 December 2016

Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code 1x07).

Drag the structure with the mouse to rotate

3D structures of undecaprenyl pyrophosphate synthase

Updated on 06-December-2016

References

  1. ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
  2. ↑ Jukic M, Rozman K, Gobec S. Recent Advances in the Development of Undecaprenyl Pyrophosphate Synthase Inhibitors as Potential Antibacterials. Curr Med Chem. 2016;23(5):464-82. PMID:26718796
  3. ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200

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