Uracil glycosylase inhibitor
From Proteopedia
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<StructureSection load='1uug' size='400' side='right' caption='Structure of uracil glycosylase inhibitor (green) complex with uracil DNA glycosylase (grey) (PDB entry [[1uug]])' scene=''> | <StructureSection load='1uug' size='400' side='right' caption='Structure of uracil glycosylase inhibitor (green) complex with uracil DNA glycosylase (grey) (PDB entry [[1uug]])' scene=''> | ||
| - | '''Uracil glycosylase inhibitor''' (UGI) is a small protein from ''Bacillus subtilis'' bacteriophage PBS1 which inhibits ''E. coli'' and other species’ uracil DNA glycosylase (UDG). UGI can disassociate UDG:DNA complexes. | + | == Function == |
| + | '''Uracil glycosylase inhibitor''' (UGI) is a small protein from ''Bacillus subtilis'' bacteriophage PBS1 which inhibits ''E. coli'' and other species’ uracil DNA glycosylase (UDG). UGI can disassociate UDG:DNA complexes<ref>PMID:12855717</ref>. | ||
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| + | == Structural highlights == | ||
| + | The surface interactions between the UGD and UGI is fairly polar<ref>PMID:10080896</ref>. | ||
==3D structures of uracil glycosylase inhibitor== | ==3D structures of uracil glycosylase inhibitor== | ||
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| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1ugi]], [[2ugi]] – UGI<br /> | [[1ugi]], [[2ugi]] – UGI<br /> | ||
Revision as of 09:35, 6 December 2016
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References
- ↑ Acharya N, Kumar P, Varshney U. Complexes of the uracil-DNA glycosylase inhibitor protein, Ugi, with Mycobacterium smegmatis and Mycobacterium tuberculosis uracil-DNA glycosylases. Microbiology. 2003 Jul;149(Pt 7):1647-58. PMID:12855717 doi:http://dx.doi.org/10.1099/mic.0.26228-0
- ↑ Putnam CD, Shroyer MJ, Lundquist AJ, Mol CD, Arvai AS, Mosbaugh DW, Tainer JA. Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase. J Mol Biol. 1999 Mar 26;287(2):331-46. PMID:10080896 doi:10.1006/jmbi.1999.2605
