Urease accessory protein

From Proteopedia

Revision as of 08:13, 8 December 2016

spinqualitylabelsall models Structure of UreE complex with formate and Ni+2 (PDB code 3tj8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Urease accessory protein (Ure) is a Ni-containing urea hydrolase involved in nitrogen recycling from arginine, ureide and purines. Ure proteins are involved in urease activation by the transfer of Ni into the protein[1]. For details see Molecular Playground/UreE. Structural highlights The Ni+2 ion coordinates six ligands which include 3 His residues belonging to the two monomers, Glu from a symmetry-related monomer, water molecule and an unidentified ligand which may be a His from an unobserved part of the chain[2]

3D structures of urease accessory protein

Updated on 08-December-2016

References

1. ↑ Witte CP, Isidore E, Tiller SA, Davies HV, Taylor MA. Functional characterisation of urease accessory protein G (ureG) from potato. Plant Mol Biol. 2001 Jan;45(2):169-79. PMID:11289508
2. ↑ Banaszak K, Martin-Diaconescu V, Bellucci M, Zambelli B, Rypniewski W, Maroney MJ, Ciurli S. Crystallographic and X-ray absorption spectroscopic characterization of Helicobacter pylori UreE bound to Ni2+ and Zn2+ reveal a role for the disordered C-terminal arm in metal trafficking. Biochem J. 2011 Oct 20. PMID:22010876 doi:10.1042/BJ20111659