Uridine 5'-monophosphate synthase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<StructureSection load='2v30' size='340' side='right' caption='Human uridine 5-monophosphate synthase OPD subunit dimer complex with UMP (stick model), [[2v30]]' scene='' > | <StructureSection load='2v30' size='340' side='right' caption='Human uridine 5-monophosphate synthase OPD subunit dimer complex with UMP (stick model), [[2v30]]' scene='' > | ||
| - | '''Uridine 5’-monophosphate synthase''' (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP). UMPS N-terminal domain is an '''orotate phosphoribosyl transferase''' (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is '''orotidine 5’-phosphate decarboxylase''' (OPD) which decarboxylates OMP to form UMP. | + | == Function == |
| + | '''Uridine 5’-monophosphate synthase''' (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP)<ref>PMID:8631878</ref>. UMPS N-terminal domain is an '''orotate phosphoribosyl transferase''' (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is '''orotidine 5’-phosphate decarboxylase''' (OPD) which decarboxylates OMP to form UMP. | ||
| + | |||
| + | == Disease == | ||
| + | Defects in UMPS result in the hereditary rare metabolic disease orotic aciduria<ref>PMID:25757096</ref>. UMPS deficiency in Holstein cattle results in an autosomal disorder which causes early embryonic death of offspring<ref>PMID:8486364</ref>. | ||
| + | |||
| + | == Structural highlights == | ||
| + | |||
</StructureSection> | </StructureSection> | ||
==3D structures of uridine 5'-monophosphate synthase== | ==3D structures of uridine 5'-monophosphate synthase== | ||
Revision as of 09:25, 8 December 2016
| |||||||||||
3D structures of uridine 5'-monophosphate synthase
Updated on 08-December-2016
References
- ↑ Yablonski MJ, Pasek DA, Han BD, Jones ME, Traut TW. Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase. J Biol Chem. 1996 May 3;271(18):10704-8. PMID:8631878
- ↑ Grohmann K, Lauffer H, Lauenstein P, Hoffmann GF, Seidlitz G. Hereditary orotic aciduria with epilepsy and without megaloblastic anemia. Neuropediatrics. 2015 Apr;46(2):123-5. doi: 10.1055/s-0035-1547341. Epub 2015 Mar, 10. PMID:25757096 doi:http://dx.doi.org/10.1055/s-0035-1547341
- ↑ Schwenger B, Schober S, Simon D. DUMPS cattle carry a point mutation in the uridine monophosphate synthase gene. Genomics. 1993 Apr;16(1):241-4. PMID:8486364 doi:http://dx.doi.org/10.1006/geno.1993.1165
