1qbh
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1qbh |SIZE=350|CAPTION= <scene name='initialview01'>1qbh</scene> | |PDB= 1qbh |SIZE=350|CAPTION= <scene name='initialview01'>1qbh</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qbh OCA], [http://www.ebi.ac.uk/pdbsum/1qbh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qbh RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Norton, R S.]] | [[Category: Norton, R S.]] | ||
[[Category: Vaux, D L.]] | [[Category: Vaux, D L.]] | ||
| - | [[Category: ZN]] | ||
[[Category: baculoviral iap repeat (bir)]] | [[Category: baculoviral iap repeat (bir)]] | ||
[[Category: inhibitor of apoptosis (iap)]] | [[Category: inhibitor of apoptosis (iap)]] | ||
| Line 32: | Line 34: | ||
[[Category: zinc binding domain]] | [[Category: zinc binding domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:11:24 2008'' |
Revision as of 20:11, 30 March 2008
| |||||||
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT
Overview
Members of the inhibitor of apoptosis (IAP) family of proteins are able to inhibit cell death following viral infection, during development or in cell lines in vitro. All IAP proteins bear one or more baculoviral IAP repeats (BIRs). Here we describe the solution structure of the third BIR domain from the mammalian IAP homolog B (MIHB/c-IAP-1). The BIR domain has a novel fold that is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues. The structure consists of a series of short alpha-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs.
About this Structure
1QBH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat., Hinds MG, Norton RS, Vaux DL, Day CL, Nat Struct Biol. 1999 Jul;6(7):648-51. PMID:10404221
Page seeded by OCA on Sun Mar 30 23:11:24 2008
