5dhl
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Toxin, mutant N197W== | |
| - | + | <StructureSection load='5dhl' size='340' side='right' caption='[[5dhl]], [[Resolution|resolution]] 2.67Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5dhl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DHL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dhl OCA], [http://pdbe.org/5dhl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dhl RCSB], [http://www.ebi.ac.uk/pdbsum/5dhl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dhl ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TACY_CLOPE TACY_CLOPE]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation.<ref>PMID:17328912</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gorman, M A]] | ||
| + | [[Category: Lawrence, S L]] | ||
| + | [[Category: Parker, M W]] | ||
| + | [[Category: Mutant]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 19:44, 9 December 2016
Crystal structure of Toxin, mutant N197W
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Categories: Gorman, M A | Lawrence, S L | Parker, M W | Mutant | Toxin
