5ego
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==HOXB13-MEIS1 heterodimer bound to methylated DNA== | |
| - | + | <StructureSection load='5ego' size='340' side='right' caption='[[5ego]], [[Resolution|resolution]] 2.54Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ego]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EGO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ego FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ego OCA], [http://pdbe.org/5ego PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ego RCSB], [http://www.ebi.ac.uk/pdbsum/5ego PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ego ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/MEIS1_HUMAN MEIS1_HUMAN]] Disease susceptibility may be associated with variations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HXB13_HUMAN HXB13_HUMAN]] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. [[http://www.uniprot.org/uniprot/MEIS1_HUMAN MEIS1_HUMAN]] Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.<ref>PMID:12609849</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Jolma, A]] | ||
| + | [[Category: Morgunova, E]] | ||
[[Category: Popov, A]] | [[Category: Popov, A]] | ||
| - | [[Category: | + | [[Category: Taipale, J]] |
[[Category: Yin, Y]] | [[Category: Yin, Y]] | ||
| - | [[Category: | + | [[Category: Bound to dna]] |
| - | [[Category: | + | [[Category: Complex]] |
| + | [[Category: Heterodimer]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription factor]] | ||
Revision as of 19:44, 9 December 2016
HOXB13-MEIS1 heterodimer bound to methylated DNA
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