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5eig

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'''Unreleased structure'''
 
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The entry 5eig is ON HOLD until Feb 25 2018
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==Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine==
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<StructureSection load='5eig' size='340' side='right' caption='[[5eig]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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Authors: Yan, W., Zhang, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5eig]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EIG FirstGlance]. <br>
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Description: Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5OW:(2~{S})-2-AZANYL-6-[[(~{Z})-~{C}-[2-METHYL-3-OXIDANYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]-~{N}-[(2~{R})-1-OXIDANYL-1-OXIDANYLIDENE-3-SULFANYL-PROPAN-2-YL]CARBONIMIDOYL]AMINO]HEXANOIC+ACID'>5OW</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cystathionine_gamma-lyase Cystathionine gamma-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.1 4.4.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eig OCA], [http://pdbe.org/5eig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eig RCSB], [http://www.ebi.ac.uk/pdbsum/5eig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eig ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/CGL_HUMAN CGL_HUMAN]] Defects in CTH are the cause of cystathioninuria (CSTNU) [MIM:[http://omim.org/entry/219500 219500]]. It is an autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine, leading to increased urinary excretion.<ref>PMID:18476726</ref> <ref>PMID:12574942</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/CGL_HUMAN CGL_HUMAN]] Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.<ref>PMID:19261609</ref> <ref>PMID:22169477</ref> <ref>PMID:19019829</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cystathionine gamma-lyase]]
[[Category: Yan, W]]
[[Category: Yan, W]]
[[Category: Zhang, J]]
[[Category: Zhang, J]]
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[[Category: Lyase]]

Revision as of 19:45, 9 December 2016

Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine

5eig, resolution 2.70Å

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