5l0m
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==hLRH-1 DNA Binding Domain - 12bp Oct4 promoter complex== | |
| - | + | <StructureSection load='5l0m' size='340' side='right' caption='[[5l0m]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5l0m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L0M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l0m OCA], [http://pdbe.org/5l0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l0m RCSB], [http://www.ebi.ac.uk/pdbsum/5l0m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l0m ProSAT]</span></td></tr> |
| - | [[Category: Tuntland, M | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ortlund, E A]] | ||
| + | [[Category: Tuntland, M L]] | ||
| + | [[Category: Dbd]] | ||
| + | [[Category: Lrh-1]] | ||
| + | [[Category: Nuclear receptor]] | ||
| + | [[Category: Oct4]] | ||
| + | [[Category: Transcription-dna complex]] | ||
Revision as of 19:53, 9 December 2016
hLRH-1 DNA Binding Domain - 12bp Oct4 promoter complex
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