1qg3
From Proteopedia
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|PDB= 1qg3 |SIZE=350|CAPTION= <scene name='initialview01'>1qg3</scene>, resolution 2.15Å | |PDB= 1qg3 |SIZE=350|CAPTION= <scene name='initialview01'>1qg3</scene>, resolution 2.15Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene> | + | |LIGAND= <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= ITGB4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= ITGB4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qg3 OCA], [http://www.ebi.ac.uk/pdbsum/1qg3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qg3 RCSB]</span> | ||
}} | }} | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known disease associated with this structure: Epidermolysis bullosa of hands and feet OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147557 147557]], Epidermolysis bullosa, generalized atrophic benign OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147557 147557]], Epidermolysis bullosa, junctional, with pyloric atresia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147557 147557]] |
==About this Structure== | ==About this Structure== | ||
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[[Category: Pereda, J Maria De.]] | [[Category: Pereda, J Maria De.]] | ||
[[Category: Wiche, G.]] | [[Category: Wiche, G.]] | ||
| - | [[Category: CAC]] | ||
| - | [[Category: SO4]] | ||
[[Category: carcinoma]] | [[Category: carcinoma]] | ||
[[Category: fibronectin]] | [[Category: fibronectin]] | ||
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[[Category: integrin]] | [[Category: integrin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:13:03 2008'' |
Revision as of 20:13, 30 March 2008
| |||||||
| , resolution 2.15Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | ITGB4 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF A TANDEM PAIR OF FIBRONECTIN TYPE III DOMAINS FROM THE CYTOPLASMIC TAIL OF INTEGRIN ALPHA6 BETA4
Contents |
Overview
The integrin alpha6beta4 is an essential component of hemidesmosomes but it also plays a dynamic role in invasive carcinoma cells. The cytoplasmic tail of the beta4 subunit is uniquely large among integrins and includes two pairs of fibronectin type III domains separated by a connecting segment. Here we describe the crystal structure of the first tandem domain pair, a module that is critical for alpha6beta4 function. The structure reveals a novel interdomain interface and candidate protein-binding sites, including a large acidic cleft formed from the surfaces of both domains and a prominent loop that is reminiscent of the RGD integrin-binding loop of fibronectin. This is the first crystal structure of either a hemidesmosome component or an integrin cytoplasmic domain, and it will enable the intracellular functions of alpha6beta4 to be dissected at the atomic level.
Disease
Known disease associated with this structure: Epidermolysis bullosa of hands and feet OMIM:[147557], Epidermolysis bullosa, generalized atrophic benign OMIM:[147557], Epidermolysis bullosa, junctional, with pyloric atresia OMIM:[147557]
About this Structure
1QG3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha6beta4., de Pereda JM, Wiche G, Liddington RC, EMBO J. 1999 Aug 2;18(15):4087-95. PMID:10428948
Page seeded by OCA on Sun Mar 30 23:13:03 2008
