1qhi
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1qhi |SIZE=350|CAPTION= <scene name='initialview01'>1qhi</scene>, resolution 1.9Å | |PDB= 1qhi |SIZE=350|CAPTION= <scene name='initialview01'>1qhi</scene>, resolution 1.9Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=BPG:9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE'>BPG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qhi OCA], [http://www.ebi.ac.uk/pdbsum/1qhi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qhi RCSB]</span> | ||
}} | }} | ||
| Line 16: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1QHI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 1QHI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHI OCA]. |
==Reference== | ==Reference== | ||
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir., Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR, FEBS Lett. 1999 Jan 25;443(2):121-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9989588 9989588] | Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir., Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR, FEBS Lett. 1999 Jan 25;443(2):121-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9989588 9989588] | ||
| - | [[Category: Human herpesvirus | + | [[Category: Human herpesvirus 1]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thymidine kinase]] | [[Category: Thymidine kinase]] | ||
| Line 32: | Line 35: | ||
[[Category: Wien, F.]] | [[Category: Wien, F.]] | ||
[[Category: Wright, G.]] | [[Category: Wright, G.]] | ||
| - | [[Category: | + | [[Category: alphaherpesvirinae novel inhibitor]] |
| - | [[Category: | + | [[Category: ds-dna enveloped viruse]] |
| + | [[Category: herpesviridae]] | ||
[[Category: transferase]] | [[Category: transferase]] | ||
| - | [[Category: transferase ( phosphotransferase) thymidine kinase | + | [[Category: transferase ( phosphotransferase) thymidine kinase]] |
[[Category: transferase (phosphotransferase) thymidine]] | [[Category: transferase (phosphotransferase) thymidine]] | ||
| + | [[Category: viridae]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:13:39 2008'' |
Revision as of 20:13, 30 March 2008
| |||||||
| , resolution 1.9Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Activity: | Thymidine kinase, with EC number 2.7.1.21 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE
Overview
Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for treatment of recurrent herpes infection and in gene therapy systems where thymidine kinase is expressed, two high-resolution X-ray structures of thymidine kinase have been compared: one with the relatively poor substrate aciclovir (Zovirax), the other with a synthetic inhibitor having an N2-substituted guanine. Both compounds have similar binding modes in spite of their size difference and apparently distinct ligand properties.
About this Structure
1QHI is a Single protein structure of sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.
Reference
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir., Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR, FEBS Lett. 1999 Jan 25;443(2):121-5. PMID:9989588
Page seeded by OCA on Sun Mar 30 23:13:39 2008
Categories: Human herpesvirus 1 | Single protein | Thymidine kinase | Batuwangala, T. | Bennett, M S. | Champness, J N. | Rutherford, T. | Sanderson, M R. | Summers, W C. | Sun, H. | Wien, F. | Wright, G. | Alphaherpesvirinae novel inhibitor | Ds-dna enveloped viruse | Herpesviridae | Transferase | Transferase ( phosphotransferase) thymidine kinase | Transferase (phosphotransferase) thymidine | Viridae
