5enn
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of Human VPS34 in complex with a selective and potent inhibitor== |
| - | + | <StructureSection load='5enn' size='340' side='right' caption='[[5enn]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5enn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ENN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ENN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5QS:1-[[4-(CYCLOPROPYLMETHYL)-5-[2-(PYRIDIN-4-YLAMINO)PYRIMIDIN-4-YL]PYRIMIDIN-2-YL]AMINO]-2-METHYL-PROPAN-2-OL'>5QS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ph4|4ph4]]</td></tr> |
| - | [[Category: Kearney, E | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5enn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5enn OCA], [http://pdbe.org/5enn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5enn RCSB], [http://www.ebi.ac.uk/pdbsum/5enn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5enn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Phosphatidylinositol 3-kinase]] | ||
| + | [[Category: Kearney, E P]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
| + | [[Category: Vps34]] | ||
Revision as of 03:22, 10 December 2016
The crystal structure of Human VPS34 in complex with a selective and potent inhibitor
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