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5jpc
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Joint X-ray/neutron structure of MTAN complex with Formycin A== | |
| - | + | <StructureSection load='5jpc' size='340' side='right' caption='[[5jpc]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5jpc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JPC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=FMC:(1S)-1-(7-AMINO-1H-PYRAZOLO[4,3-D]PYRIMIDIN-3-YL)-1,4-ANHYDRO-D-RIBITOL'>FMC</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5k1z|5k1z]]</td></tr> |
| - | [[Category: Kovalevsky, A | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jpc OCA], [http://pdbe.org/5jpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jpc RCSB], [http://www.ebi.ac.uk/pdbsum/5jpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jpc ProSAT]</span></td></tr> |
| - | [[Category: Ronning, D | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/MQMTN_HELPJ MQMTN_HELPJ]] Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Helicobacter species. Also catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Can also probably use S-adenosylhomocysteine (SAH) as substrate, leading to adenine and S-ribosylhomocysteine. These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2.<ref>PMID:20954236</ref> <ref>PMID:22891633</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Banco, M T]] | ||
| + | [[Category: Kovalevsky, A Y]] | ||
| + | [[Category: Ronning, D R]] | ||
| + | [[Category: Helicobacter pylori]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Joint neutron and x-ray]] | ||
| + | [[Category: Neutron]] | ||
| + | [[Category: Nucleosidase]] | ||
Revision as of 03:27, 10 December 2016
Joint X-ray/neutron structure of MTAN complex with Formycin A
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