5eov
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==C-terminal domain of the 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA.== | |
| - | + | <StructureSection load='5eov' size='340' side='right' caption='[[5eov]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5eov]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EOV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eov OCA], [http://pdbe.org/5eov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eov RCSB], [http://www.ebi.ac.uk/pdbsum/5eov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eov ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[Category: Conn, G | + | [[http://www.uniprot.org/uniprot/TLYA_MYCTO TLYA_MYCTO]] Acts as a host evasion factor, that significantly contributes to the pathogenesis of M.tuberculosis by modulating adaptive immune responses by inhibiting host-protective Th1 and Th17 cytokine responses as well as autophagy. Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Is likely involved in ribosomal biogenesis. Also exhibits hemolytic activity in vitro, by binding with and oligomerizing into host cell membranes.[UniProtKB:P9WJ63] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Conn, G L]] | ||
| + | [[Category: Witek, M A]] | ||
| + | [[Category: Antibiotic sensitivity]] | ||
| + | [[Category: Methyltransferase]] | ||
| + | [[Category: Ribosome]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 10:47, 10 December 2016
C-terminal domain of the 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA.
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