5ep7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5ep7" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5ep7 is ON HOLD until Nov 11 2017
+
==Crystal structure of the bromodomain of human CREBBP in complex with UN32==
-
 
+
<StructureSection load='5ep7' size='340' side='right' caption='[[5ep7]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
-
Authors: Dong, J., Caflisch, A.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5ep7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EP7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EP7 FirstGlance]. <br>
-
Description: Crystal structure of the bromodomain of human CREBBP in complex with UN32
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5QR:3-[(1-METHYL-6-OXIDANYLIDENE-PYRIDIN-3-YL)CARBONYLAMINO]BENZOIC+ACID'>5QR</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ep7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ep7 OCA], [http://pdbe.org/5ep7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ep7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ep7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ep7 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Histone acetyltransferase]]
 +
[[Category: Caflisch, A]]
[[Category: Dong, J]]
[[Category: Dong, J]]
-
[[Category: Caflisch, A]]
+
[[Category: Inhibitor]]
 +
[[Category: Transcription]]
 +
[[Category: Transferase]]

Revision as of 10:48, 10 December 2016

Crystal structure of the bromodomain of human CREBBP in complex with UN32

5ep7, resolution 1.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ep7"
Personal tools